Results 141 to 150 of about 2,042,169 (305)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Characteristics of wideband dipole phased array of L-band
Известия высших учебных заведений России: Радиоэлектроника, 2015 Results of designing of broadband equidistant phased antenna array (PAA) of UHF range, built on the basis of dipole emitters are shown. Frequency dependences of the reflection coefficients in the path of the power elements in the infinite PAA, as well as
S. V. Ballandovich +4 more
doaj
Dynamic characteristic analysis of vertical screw conveyor in variable screw section condition. [PDF]
Sci Prog, 2020 Yuan J, Li M, Ye F, Zhou Z.
europepmc +1 more source
Dynamic characteristics of a pendulum system
, 2009 The main objective of this master thesis is to study a pendulum system. This thesis was placed within a project wich is research for the improvement of the wave power generation energy system. The thesis consisted of modelling, simulation and experimental work.
openaire +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Dynamic characteristic analysis and startup optimization design of an intermediate drive belt conveyor with non-uniform load. [PDF]
Sci Prog, 2020 Feng Y, Zhang M, Li G, Meng G.
europepmc +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
BuildingsUsing coal gangue as a subgrade filler will produce good benefits, and its application prospects are very broad. It is of great engineering and scientific value to study the improvement method and dynamic characteristics of coal gangue subgrade filler ...
Hemeng Zhang +3 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source