Results 41 to 50 of about 566,262 (312)

Field Research on the Wind-Induced Response of a Super High-Rise Building under Typhoon

open access: yesApplied Sciences, 2019
This paper simultaneously measures the characteristics of wind on the roof and the acceleration responses of the 10th, 18th, 25th, 32nd and 41st floors of a high-rise building in Wenzhou during the passing of typhoons between 2014 and 2016.
Chequan Wang   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

The influence of pre-existing vibrations on the dynamic response of medium span bridges

open access: yes, 2009
Critical static bridge loading scenarios are often expressed in terms of the number of vehicles that are present on the bridge at the time of occurrence of maximum lifetime load effect.
O'Brien, Eugene J.   +2 more
core   +1 more source

Design and Performance Analysis of a High-Temperature Forging Deformation Simulation Device for Dual Manipulators

open access: yesMachines
To address the difficulty of directly detecting internal stresses in high-temperature forgings during dual-manipulator control experiments and the significant safety risks associated with high-temperature environments, this study developed an ...
Xiaonan Wang   +5 more
doaj   +1 more source

Dispersive dynamics in the characteristic moving frame [PDF]

open access: yesProceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2019
A mechanism for dispersion to automatically arise from the dispersionless Whitham Modulation equations (WMEs) is presented, relying on the use of a moving frame. The speed of this is chosen to be one of the characteristics which emerge from the linearization of the Whitham system, and assuming these are real (and thus the WMEs are hyperbolic) morphs ...
openaire   +4 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Experimental study on dynamic characteristics of calcareous sand-gravel mixtures from islands in the South China Sea

open access: yesYantu gongcheng xuebao
In the construction process of reef islands in the South China Sea, the upper reclamation foundation materials exist in the form of a combination of large calcareous gravels and small calcareous sand mixed in random proportions.
WU Yang 1, WU Yihang 1, 2, MA Linjian 3, CUI Jie 1, LIU Jiankun 2, DAI Beibing 2
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Characteristic dynamic traffic load effects in bridges

open access: yes, 2009
When formulating an approach to assess bridge traffic loading with allowance for Vehicle-Bridge Interaction (VBI), a trade-off is necessary between the limited accuracy and computational demands of numerical models and the limited time periods for which ...
O\u27Brien, Eugene J.   +10 more
core   +1 more source

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