Results 61 to 70 of about 566,262 (312)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
World Electric Vehicle JournalThis study investigates the dynamic characteristics of electro-hydrostatic actuators (EHA), which serve as the core actuating element in vehicle active suspension systems, with the aim of enhancing overall system performance. The purpose of this research
Peng Chen, Xing Chen
doaj +1 more source
IEEE Access, 2019 The accurate prediction and research about the dynamic characteristic of machine tool during the design process are essential to develop high-performance machines.
Yang Yong +3 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Simulation and Analysis of Dynamic Characteristic of Air Spring in Railway Vehicles
机车电传动, 2013 Based on the mathematical and physical equations of thermodynamics and fluid mechanics theories, the bellow-fixed orificeauxiliary tank model and the bellow-pipe-auxiliary tank model of air spring were established respectively.
LIU Ya-ping +3 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Simulation of Dynamic Characteristic for Parallel Machine Tool
, 2011 The dynamic characteristics of parallel 3-TPT machine tool are researched by simulation and experiment in this paper. Firstly, modal analysis principle of machine tool was analyzed in theory, and the parameters of dynamic characteristic were identified ...
Chun Xia Zhu, Ji Man Luo, Bin Li
core +1 more source
Effects of Fastener Failure at Different Parts on Rotor Systems Outputs
IEEE Access, 2019 The fastener failures at different parts have diverse influences on the outputs of rotor systems. However, little research about this has been reported yet. Thus, the influences of various fastener failures on rotor outputs are investigated in this paper.
Hui Yu, Genbao Zhang, Wei Zhou
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source