Results 91 to 100 of about 238,828 (294)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cycling-Induced Degradation Analysis of Lithium-Ion Batteries Under Static and Dynamic Charging: A Physical Testing Methodology Using Low-Cost Equipment

World Electric Vehicle Journal
Given the rising importance of cost-effective solutions in battery research, this study employs an accessible testing approach using low-cost, sensor-equipped platforms that enable broader research and educational applications.
Byron Patricio Acosta-Rivera, David Sebastian Puma-Benavides, Juan de Dios Calderon-Najera, Leonardo Sanchez-Pegueros, Edilberto Antonio Llanes-Cedeño, Iván Fernando Sinaluisa-Lozano, Bolivar Alejandro Cuaical-Angulo   +6 more
doaj   +1 more source

Enhanced energy transfer in a Dicke quantum battery

, 2018
We theoretically investigate the enhancement of the charging power in a Dicke quantum battery which consists of an array of $N$ two-level systems (TLS) coupled to a single mode of cavity photons.
blaauboer, Miriam, Zhang, Xiang
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Charge Solitons in 1-D Arrays of Serially Coupled Josephson Junctions

, 1996
We study a 1-D array of Josephson coupled superconducting grains with kinetic inductance which dominates over the Josephson inductance. In this limit the dynamics of excess Cooper pairs in the array is described in terms of charge solitons, created by ...
A. Shnirman, A. V. Ustinov, A. Widom. G. Megaloudis, C. Cha, D. E. McCumber, D. J. Bergman, D. W. McLaughlin, E. Ben-Jacob, E. Ben-Jacob, E. Ben-Jacob, E. Ben-Jacob, E. Tomboulis, Eshel Ben-Jacob, G. Schön, Gerd Schön, J. F. Currie, J. L. Gervais, K. K. Likharev, K. K. Likharev, M. Amman, M. Amman, M. Büttiker, M. H. Devoret, M. Peyrard, N. H. Christ, N. S. Bakhvalov, P. Delsing, P. M. Marcus, R. Dashen, R. Dashen, R. Jackiw, R. Rajaraman, R. Rajaraman, S. Coleman, S. M. Girvin, T. P. Orlando, U. Geigenmüller, W. C. Stewart, Y. Aharonov, Y. Aharonov, Y. Gefen, Z. Hermon, Z. Hermon A. Stern, Ziv Hermon   +43 more
core   +2 more sources

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

eLife, 2020
The recruitment of substrates by the ser/thr protein phosphatase 2A (PP2A) is poorly understood, limiting our understanding of PP2A-regulated signaling. Recently, the first PP2A:B56 consensus binding motif, LxxIxE, was identified. However, most validated LxxIxE motifs bind PP2A:B56 with micromolar affinities, suggesting that additional motifs exist to ...
Wang, Xinru, Garvanska, Dimitriya H, Nasa, Isha, Ueki, Yumi, Zhang, Gang, Kettenbach, Arminja N, Peti, Wolfgang, Nilsson, Jakob, Page, Rebecca   +8 more
openaire   +5 more sources