Results 91 to 100 of about 3,060,651 (293)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Providing Authentication & Authorization Mechanisms for Active Service Charging [PDF]

, 2002
Active network technology enables fast deployment of new network services tailored to the specific needs of end users, among others features.
Bagnulo Braun, Marcelo Gabriel, Bagnulo, Marcelo, Marifeli, Sedano, Alarcos, Bernardo, Calderón, María   +4 more
core   +1 more source

Study on charging strategy of wireless rechargeable sensor networks based on dynamic inhomogeneous clustering

Scientific Reports
In wireless rechargeable sensor networks (WRSNs), high node mortality rate severely constrains the network performance. To address this problem, this paper proposes an innovative charging strategy based on dynamic inhomogeneous clustering (DICCS).
Peng Tian, Jia Yang, Hongyu Pu, Xin Tian, Jiale Tang, Guozheng Ran, Liang Peng   +6 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A non-obtrusive technique to characterize dielectric charging in RF-MEMS capacitive switches [PDF]

, 2012
Degradation and failure due to dielectric charging has been a dominant and pervasive reliability concern for RF-MEMS switches. Traditionally, the operational lifetime dictated by this degradation phenomenon is extrapolated from a series of measurements ...
Muhammad A Alam, Alam, Muhammad A., Sambit Palit, Ankit Jain, Palit, Sambit, Jain, Ankit   +5 more
core   +1 more source

Congestion management for urban EV charging systems

We consider the problem of managing Electric Vehicle (EV) charging at charging points in a city to ensure that the load on the charging points remains within the desired limits while minimizing the inconvenience to EV owners.
Rigas, Emmanouil, Bassiliades, Nick, Ramchurn, Sarvapali, Koutitas, Georgios   +3 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Site selection and capacity determination of charging stations considering the uncertainty of users’ dynamic charging demands

Frontiers in Energy Research
Aiming at the problems of high investment and low efficiency in the planning and construction of electric vehicle (EV) charging stations in cities, an optimization model for site selection and capacity determination of charging stations considering the ...
Zhang Linjuan, Fu Han, Zhou Zhiheng, Wang Shangbing, Wang Shangbing, Zhang Jinbin   +5 more
doaj   +1 more source