Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
An Online Mechanism for Multi-Unit Demand and its Application to Plug-in Hybrid Electric Vehicle Charging [PDF]
We develop an online mechanism for the allocation of an expiring resource to a dynamic agent population. Each agent has a non-increasing marginal valuation function for the resource, and an upper limit on the number of units that can be allocated in any ...
Stein, Sebastian +5 more
core +3 more sources
Semiclassical dynamics and nonlinear charge current [PDF]
Electron conductivity is an important material property that can provide a wealth of information about the underlying system. Especially, the response of the conductivity with respect to electromagnetic fields corresponds to various nonlinear charge currents, which have distinct symmetry requirements and hence can be used as efficient probes of ...
openaire +2 more sources
A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment
The recruitment of substrates by the ser/thr protein phosphatase 2A (PP2A) is poorly understood, limiting our understanding of PP2A-regulated signaling. Recently, the first PP2A:B56 consensus binding motif, LxxIxE, was identified. However, most validated LxxIxE motifs bind PP2A:B56 with micromolar affinities, suggesting that additional motifs exist to ...
Wang, Xinru +8 more
openaire +4 more sources
Static and dynamic charged black holes [PDF]
AbstractWe consider a class of Einstein–Maxwell–dilaton theories in general dimensions and construct both static and dynamic charged black holes. We adopt the reverse engineering procedure and make a specific ansatz for the scalar field and then derive the necessary scalar potential and the non-minimal coupling function between the scalar and the ...
Huang, Hyat, Fan, Zhong-Ying, Lü, H.
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Virtual Power Plant Framework for Dynamic Power Management in EV Charging Stations
The rapid proliferation of Electric Vehicles (EVs) offers a promising pathway toward reducing greenhouse gas emissions and fostering a sustainable environment.
G. M. Shafiullah +3 more
core +1 more source
Suppression of dynamic self-discharge of supercapacitor using multi-stage charging strategy
The high self-discharge rate in carbon-based supercapacitors remains a critical challenge limiting widespread usage in applications requiring long-term energy storage.
Emmanuel Nsengiyumva +9 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Given the rising importance of cost-effective solutions in battery research, this study employs an accessible testing approach using low-cost, sensor-equipped platforms that enable broader research and educational applications.
Byron Patricio Acosta-Rivera +6 more
doaj +1 more source

