Results 31 to 40 of about 471 (209)

Design strategy of IGCT clamp circuit parameters based on bi-objective nonlinear optimization

Energy Reports, 2022
The integrated gate commutated thyristor (IGCT) is a high-power semiconductor device with excellent performance, whose operating characteristics are governed by the clamp circuit.
Tao Jiang, Xiaotao Han, Shaozhe Zhang
doaj   +1 more source

High-speed dynamic-clamp interface

Journal of Neurophysiology, 2015
The dynamic-clamp technique is highly useful for mimicking synaptic or voltage-gated conductances. However, its use remains rare in part because there are few systems, and they can be expensive and difficult for less-experienced programmers to implement.
Yang, Y., Adowski, T., Ramamurthy, B., Neef, A., Xu-Friedman, M.   +4 more
openaire   +4 more sources

The human dynamic clamp as a paradigm for social interaction [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The human dynamic clamp (HDC) is proposed as a general paradigm for studies of elementary forms of social behavior in complex biological systems. HDC enables parametric control of real-time bidirectional interaction between humans and empirically grounded theoretical models of coordination dynamics.
Guillaume, Dumas, Gonzalo C, de Guzman, Emmanuelle, Tognoli, J A Scott, Kelso   +3 more
openaire   +2 more sources

Establishment of an automated patch-clamp platform for electrophysiological and pharmacological evaluation of hiPSC-CMs

Stem Cell Research, 2019
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have evolved into widely used and reliable cell sources for modeling cardiovascular channelopathies and for drug safety pharmacology.
Wener Li, Xiaojing Luo, Ying Ulbricht, Michael Wagner, Christopher Piorkowski, Ali El-Armouche, Kaomei Guan   +6 more
doaj   +1 more source

Statistics of neuronal identification with open and closed loop measures of intrinsic excitability

Frontiers in Neural Circuits, 2012
In complex nervous systems patterns of neuronal activity and measures of intrinsic neuronal excitability are often used as criteria for identifying and/or classifying neurons.
Ted eBrookings, Rachel eGrashow, Eve eMarder   +2 more
doaj   +1 more source

Weevil endosymbiont dynamics is associated with a clamping of immunity [PDF]

BMC Genomics, 2015
Insects subsisting on nutritionally unbalanced diets have evolved long-term mutualistic relationships with intracellular symbiotic bacteria (endosymbionts). The endosymbiont population load undergoes changes along with insect development. In the cereal weevil Sitophilus oryzae, the midgut endosymbionts Sodalis pierantonius drastically multiply ...
Masson, F., Moné, Y., Vigneron, A., Vallier, A., Parisot, N., Vincent-Monégat, C., Balmand, Severine, Carpentier, M.C., Zaidman-Rémy, A., Heddi, A.   +9 more
openaire   +5 more sources

Firing clamp: A novel method for single-trial estimation of excitatory and inhibitory synaptic neuronal conductances

Frontiers in Cellular Neuroscience, 2014
Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording.
Anton eChizhov, Evgenya eMalinina, Michael eDruzin, Michael eDruzin, Lyle J Graham, Staffan eJohansson   +5 more
doaj   +1 more source

An AFM-based stiffness clamp for dynamic control of rigidity. [PDF]

PLoS ONE, 2011
Atomic force microscopy (AFM) has become a powerful tool for measuring material properties in biology and imposing mechanical boundary conditions on samples from single molecules to cells and tissues.
Kevin D Webster, Ailey Crow, Daniel A Fletcher   +2 more
doaj   +1 more source

The pros and cons of degeneracy

eLife, 2014
Drugs could treat neuropathic pain more effectively if they simultaneously targeted two or more types of ion channel.
Jean-Marc Goaillard, Martial A Dufour
doaj   +1 more source

Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain

eLife, 2014
Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability.
Stéphanie Ratté, Yi Zhu, Kwan Yeop Lee, Steven A Prescott   +3 more
doaj   +1 more source