Results 41 to 50 of about 471 (209)

Experimental Investigation and Optimization Design of Multi-Support Pipeline System

Chinese Journal of Mechanical Engineering, 2021
The design of aircraft hydraulic pipeline system is limited by many factors, such as the integrity of aviation structure or narrow installation space, so the limited clamp support position should be considered. This paper studied the frequency adjustment
Xiantao Zhang, Wei Liu, Yamei Zhang, Yujie Zhao   +3 more
doaj   +1 more source

Single-Molecule Dynamics of the Replication Sliding Clamp and Clamp Loader System [PDF]

Biophysical Journal, 2009
The sliding clamp is a conserved, ring-shaped cofactor of DNA polymerases. It encircles DNA and plays a crucial role in orchestrating many replication-related processes. In all forms of life, the sliding clamp greatly enhances the processivity of replicative DNA polymerases.
Liu, Cheng, Shi, Xinghua, Chen, Yi-Hsing, O'Cann, Isaac K., Ha, Taekjip   +4 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

eLife, 2022
Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ ATPase complexes.
Christl Gaubitz, Xingchen Liu, Joshua Pajak, Nicholas P Stone, Janelle A Hayes, Gabriel Demo, Brian A Kelch   +6 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Dynamic Study of a Capacitive MEMS Switch with Double Clamped-Clamped Microbeams [PDF]

Shock and Vibration, 2014
We study a capacitive MEMS switch composed of two clamped-clamped exible microbeams. We first develop a mathematical model for the MEMS switch where the upper microbeam represents the ground transmission line and the lower one represents the central transmission line.
Hatem Samaali, Fehmi Najar, Slim Choura
openaire   +2 more sources

An Analysis of the Vibration Characteristics of an Aviation Hydraulic Pipeline with a Clamp

Aerospace, 2023
Taking an aviation hydraulic pipeline as the research object, a fluid–solid coupling vibration model of the pipeline system, considering the influence of the clamp, is established.
Yong Liu, Jinting Wei, Hao Du, Zhenpeng He, Fangchao Yan   +4 more
doaj   +1 more source

A Numerical–Experimental Approach for Multi‐Matrix Fiber‐Reinforced Plastics Characterization Using Finite Element Model Updating

Advanced Engineering Materials, EarlyView.
A numerical–experimental framework is developed for characterizing multi‐matrix fiber‐reinforced polymers (MM‐FRPs) combining epoxy and polyurethane matrices. Harmonic bending tests are integrated with finite element model updating (FEMU) to simultaneously identify elastic and viscoelastic material parameters.
Rodrigo M. Dartora, Tales V. Lisbôa, Axel Spickenheuer, Rogério J. Marczak, Jakson M. Vassoler   +4 more
wiley   +1 more source

Clamp Nonlinear Modeling and Hysteresis Model Parameter Identification

IEEE Access, 2021
Based on the Bouc-Wen model, a nonlinear hysteretic restoring force model is established with dynamic equations. The hardening and softening of the material after reaching the yield limit are described by the nonlinear restoring force-displacement ...
Junzhe Lin, Zhihong Niu, Xufang Zhang, Hui Ma, Yulai Zhao, Qingkai Han   +5 more
doaj   +1 more source

Fatigue Crack Initiation and Growth in Nanocrystalline Ni at Multiple Length‐Scales

Advanced Engineering Materials, EarlyView.
Overview of miniaturized in situ SEM fatigue setup and resultant fatigue crack growth data for nanocrystalline Ni. The presented study focuses on the analysis of fatigue crack growth rate (FCGR) in focused ion beam‐notched microcantilevers prepared from nanocrystalline (NC) Ni as a model material.
Igor Moravcik, Alexander Jelinek, Markus Alfreider, Jutta Luksch, Anton Hohenwarter, Florian Schaefer, Christian Motz, Daniel Kiener   +7 more
wiley   +1 more source