Results 51 to 60 of about 3,107,467 (149)
Frontiers in Cellular Neuroscience, 2014 Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording.
Anton eChizhov +5 more
doaj +1 more source
The pros and cons of degeneracy
eLife, 2014 Drugs could treat neuropathic pain more effectively if they simultaneously targeted two or more types of ion channel.
Jean-Marc Goaillard, Martial A Dufour
doaj +1 more source
An AFM-based stiffness clamp for dynamic control of rigidity. [PDF]
PLoS ONE, 2011 Atomic force microscopy (AFM) has become a powerful tool for measuring material properties in biology and imposing mechanical boundary conditions on samples from single molecules to cells and tissues.
Kevin D Webster +2 more
doaj +1 more source
Weevil endosymbiont dynamics is associated with a clamping of immunity [PDF]
BMC Genomics, 2015 Insects subsisting on nutritionally unbalanced diets have evolved long-term mutualistic relationships with intracellular symbiotic bacteria (endosymbionts). The endosymbiont population load undergoes changes along with insect development. In the cereal weevil Sitophilus oryzae, the midgut endosymbionts Sodalis pierantonius drastically multiply ...
Masson, F. +9 more
openaire +5 more sources
eLife, 2014 Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability.
Stéphanie Ratté +3 more
doaj +1 more source
Experimental Investigation and Optimization Design of Multi-Support Pipeline System
Chinese Journal of Mechanical Engineering, 2021 The design of aircraft hydraulic pipeline system is limited by many factors, such as the integrity of aviation structure or narrow installation space, so the limited clamp support position should be considered. This paper studied the frequency adjustment
Xiantao Zhang +3 more
doaj +1 more source
Single-Molecule Dynamics of the Replication Sliding Clamp and Clamp Loader System [PDF]
Biophysical Journal, 2009 The sliding clamp is a conserved, ring-shaped cofactor of DNA polymerases. It encircles DNA and plays a crucial role in orchestrating many replication-related processes. In all forms of life, the sliding clamp greatly enhances the processivity of replicative DNA polymerases.
Liu, Cheng +4 more
openaire +1 more source
Stress in V-section band clamps [PDF]
, 2004 This paper presents an analysis of the stresses in V-section band clamps by examining the correlation between experimental work and theoretical models.
Shoghi, K. +7 more
core +1 more source
Stem Cell Research, 2019 Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have evolved into widely used and reliable cell sources for modeling cardiovascular channelopathies and for drug safety pharmacology.
Wener Li +6 more
doaj +1 more source
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader
eLife, 2022 Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ ATPase complexes.
Christl Gaubitz +6 more
doaj +1 more source