Towards a Dynamic Clamp for Neurochemical Modalities [PDF]
Sensors, 2015 The classic dynamic clamp technique uses a real-time electrical interface between living cells and neural simulations in order to investigate hypotheses about neural function and structure.
Catalina Maria Rivera +8 more
doaj +8 more sources
Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing [PDF]
Frontiers in Physiology, 2018 Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in ...
Francis A. Ortega +4 more
doaj +4 more sources
Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp [PDF]
Frontiers in Pharmacology, 2021 Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently, novel therapies are being developed. Ultimately, the impact of compounds on the action potential (AP) needs to be tested in freshly isolated human atrial myocytes.
Arie O. Verkerk +8 more
doaj +4 more sources
Single electrode dynamic clamp with StdpC [PDF]
Journal of Neuroscience Methods, 2012 Dynamic clamp is a powerful approach for electrophysiological investigations allowing researchers to introduce artificial electrical components into target neurons to simulate ionic conductances, chemical or electrotonic inputs or connections to other cells.
Michael Crossley +2 more
exaly +4 more sources
Generalization of the dynamic clamp concept in neurophysiology and behavior. [PDF]
PLoS ONE, 2012 The idea of closed-loop interaction in in vitro and in vivo electrophysiology has been successfully implemented in the dynamic clamp concept strongly impacting the research of membrane and synaptic properties of neurons.
Pablo Chamorro +5 more
doaj +6 more sources
Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp [PDF]
Frontiers in Pharmacology, 2022 The congenital short QT syndrome (SQTS) is a cardiac condition that leads to abbreviated ventricular repolarization and an increased susceptibility to arrhythmia and sudden death.
Chunyun Du +9 more
doaj +2 more sources
A dynamic clamp protocol to artificially modify cell capacitance [PDF]
eLife, 2022 Dynamics of excitable cells and networks depend on the membrane time constant, set by membrane resistance and capacitance. Whereas pharmacological and genetic manipulations of ionic conductances of excitable membranes are routine in electrophysiology ...
Paul Pfeiffer +5 more
doaj +2 more sources
Injection of IK1 through dynamic clamp can make all the difference in patch-clamp studies on hiPSC-derived cardiomyocytes [PDF]
Frontiers in Physiology, 2023 Human-induced stem cell-derived cardiomyocytes (hiPSC-CMs) are a valuable tool for studying development, pharmacology, and (inherited) arrhythmias. Unfortunately, hiPSC-CMs are depolarized and spontaneously active, even the working cardiomyocyte subtypes
Arie O. Verkerk +2 more
doaj +2 more sources
A Dynamic Clamp on Every Rig. [PDF]
eNeuro, 2017 AbstractThe dynamic clamp should be a standard part of every cellular electrophysiologist’s toolbox. That it is not, even 25 years after its introduction, comes down to three issues: money, the disruption that adding dynamic clamp to an existing electrophysiology rig entails, and the technical prowess required of experimenters.
Desai NS, Gray R, Johnston D.
europepmc +4 more sources
StdpC: A modern dynamic clamp [PDF]
Journal of Neuroscience Methods, 2006 With the advancement of computer technology many novel uses of dynamic clamp have become possible. We have added new features to our dynamic clamp software StdpC ("Spike timing-dependent plasticity Clamp") allowing such new applications while conserving the ease of use and installation of the popular earlier Dynclamp 2/4 package. Here, we introduce the
Attila Szücs +2 more
exaly +3 more sources