Results 31 to 40 of about 477 (209)

Functional correlates of clinical phenotype and severity in recurrent SCN2A variants

Communications Biology, 2022
A comprehensive biophysical analysis of disease-associated mutations in the voltage-gated sodium channel gene, SCN2A, suggests that dynamic action potential clamp may be a better predictor than voltage clamp of how these mutations alter neuronal ...
Géza Berecki, Katherine B. Howell, Jacqueline Heighway, Nelson Olivier, Jill Rodda, Isabella Overmars, Danique R. M. Vlaskamp, Tyson L. Ware, Simone Ardern-Holmes, Gaetan Lesca, Michael Alber, Pierangelo Veggiotti, Ingrid E. Scheffer, Samuel F. Berkovic, Markus Wolff, Steven Petrou   +15 more
doaj   +1 more source

Establishment of an automated patch-clamp platform for electrophysiological and pharmacological evaluation of hiPSC-CMs

Stem Cell Research, 2019
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have evolved into widely used and reliable cell sources for modeling cardiovascular channelopathies and for drug safety pharmacology.
Wener Li, Xiaojing Luo, Ying Ulbricht, Michael Wagner, Christopher Piorkowski, Ali El-Armouche, Kaomei Guan   +6 more
doaj   +1 more source

Weevil endosymbiont dynamics is associated with a clamping of immunity [PDF]

BMC Genomics, 2015
Insects subsisting on nutritionally unbalanced diets have evolved long-term mutualistic relationships with intracellular symbiotic bacteria (endosymbionts). The endosymbiont population load undergoes changes along with insect development. In the cereal weevil Sitophilus oryzae, the midgut endosymbionts Sodalis pierantonius drastically multiply ...
Masson, F., Moné, Y., Vigneron, A., Vallier, A., Parisot, N., Vincent-Monégat, C., Balmand, Severine, Carpentier, M.C., Zaidman-Rémy, A., Heddi, A.   +9 more
openaire   +5 more sources

Statistics of neuronal identification with open and closed loop measures of intrinsic excitability

Frontiers in Neural Circuits, 2012
In complex nervous systems patterns of neuronal activity and measures of intrinsic neuronal excitability are often used as criteria for identifying and/or classifying neurons.
Ted eBrookings, Rachel eGrashow, Eve eMarder   +2 more
doaj   +1 more source

The human dynamic clamp as a paradigm for social interaction [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The human dynamic clamp (HDC) is proposed as a general paradigm for studies of elementary forms of social behavior in complex biological systems. HDC enables parametric control of real-time bidirectional interaction between humans and empirically grounded theoretical models of coordination dynamics.
Guillaume, Dumas, Gonzalo C, de Guzman, Emmanuelle, Tognoli, J A Scott, Kelso   +3 more
openaire   +2 more sources

Firing clamp: A novel method for single-trial estimation of excitatory and inhibitory synaptic neuronal conductances

Frontiers in Cellular Neuroscience, 2014
Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording.
Anton eChizhov, Evgenya eMalinina, Michael eDruzin, Michael eDruzin, Lyle J Graham, Staffan eJohansson   +5 more
doaj   +1 more source

An AFM-based stiffness clamp for dynamic control of rigidity. [PDF]

PLoS ONE, 2011
Atomic force microscopy (AFM) has become a powerful tool for measuring material properties in biology and imposing mechanical boundary conditions on samples from single molecules to cells and tissues.
Kevin D Webster, Ailey Crow, Daniel A Fletcher   +2 more
doaj   +1 more source

High-speed dynamic-clamp interface

Journal of Neurophysiology, 2015
The dynamic-clamp technique is highly useful for mimicking synaptic or voltage-gated conductances. However, its use remains rare in part because there are few systems, and they can be expensive and difficult for less-experienced programmers to implement.
Yang, Yang, Adowski, Timothy, Ramamurthy, Bina, Neef, Andreas, Xu-Friedman, Matthew A   +4 more
openaire   +5 more sources

The pros and cons of degeneracy

eLife, 2014
Drugs could treat neuropathic pain more effectively if they simultaneously targeted two or more types of ion channel.
Jean-Marc Goaillard, Martial A Dufour
doaj   +1 more source

Dynamic Study of a Capacitive MEMS Switch with Double Clamped-Clamped Microbeams [PDF]

Shock and Vibration, 2014
We study a capacitive MEMS switch composed of two clamped-clamped exible microbeams. We first develop a mathematical model for the MEMS switch where the upper microbeam represents the ground transmission line and the lower one represents the central transmission line.
Hatem Samaali, Fehmi Najar, Slim Choura
openaire   +2 more sources