Results 51 to 60 of about 45,946 (274)
Single-Molecule Dynamics of the Replication Sliding Clamp and Clamp Loader System [PDF]
Biophysical Journal, 2009 The sliding clamp is a conserved, ring-shaped cofactor of DNA polymerases. It encircles DNA and plays a crucial role in orchestrating many replication-related processes. In all forms of life, the sliding clamp greatly enhances the processivity of replicative DNA polymerases.
Liu, Cheng +4 more
openaire +1 more source
eLife, 2014 Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability.
Stéphanie Ratté +3 more
doaj +1 more source
Experimental Investigation and Optimization Design of Multi-Support Pipeline System
Chinese Journal of Mechanical Engineering, 2021 The design of aircraft hydraulic pipeline system is limited by many factors, such as the integrity of aviation structure or narrow installation space, so the limited clamp support position should be considered. This paper studied the frequency adjustment
Xiantao Zhang +3 more
doaj +1 more source
Dynamic Study of a Capacitive MEMS Switch with Double Clamped-Clamped Microbeams [PDF]
Shock and Vibration, 2014 We study a capacitive MEMS switch composed of two clamped-clamped exible microbeams. We first develop a mathematical model for the MEMS switch where the upper microbeam represents the ground transmission line and the lower one represents the central transmission line.
Hatem Samaali, Fehmi Najar, Slim Choura
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader
eLife, 2022 Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ ATPase complexes.
Christl Gaubitz +6 more
doaj +1 more source
Dynamic Clamp in Electrophysiological Studies on Stem Cell-Derived Cardiomyocytes-Why and How?
, 2021 : Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are supposed to be a good human-based model, with virtually unlimited cell source, for studies on mechanisms underlying cardiac development and cardiac diseases, and for identification of ...
Wilders, Ronald, Verkerk, Arie O.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
An Analysis of the Vibration Characteristics of an Aviation Hydraulic Pipeline with a Clamp
Aerospace, 2023 Taking an aviation hydraulic pipeline as the research object, a fluid–solid coupling vibration model of the pipeline system, considering the influence of the clamp, is established.
Yong Liu +4 more
doaj +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source