Results 191 to 200 of about 3,165,419 (303)

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Economic evaluations of antiobesity medications: A systematic literature review

British Journal of Clinical Pharmacology, EarlyView.
The global prevalence of obesity is rising rapidly. With several antiobesity medications approved and many more in development, understanding their economic value is increasingly important. This study reviews full economic evaluations of approved antiobesity medications to assess cost‐effectiveness and inform reimbursement and access decisions.
Martina Jurković, Almir Fajkić, Andrea Katrin Faour, Mirna Momčilović, Petra Turčić, Andrej Belančić   +5 more
wiley   +1 more source

Enhanced acute absorption of vitamin D3 with a liposomal formulation (Cymbiotika) compared to a standard formulation in healthy adults: a randomized double-blind crossover study. [PDF]

Front Nutr
Briskey D, Rahman S, Raut S, Jafarieh C, Rao A.   +4 more
europepmc   +1 more source

Racial gaps without racism: How English universities frame inequality in access and participation plans

British Educational Research Journal, EarlyView.
Abstract Racial inequalities are pervasive in higher education despite concerted efforts to redress issues of access, progression and continuation. Little attention has been paid to how universities themselves construct race within their policy texts.
Benjamin Hart, Mirna Šumatić
wiley   +1 more source

Methodological Caveats, Statistical Multiplicity, and Conceptual Dichotomy in Myofascial Trigger Point-Augmented Acupuncture for Knee Osteoarthritis [Letter]. [PDF]

J Pain Res
Ye Y, Hu J.
europepmc   +1 more source

Functional Diversity and Oleaginous Potential of Fungal Strains From Hawaiian Soil Ecosystems

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Fungi represent an important but underexplored resource for microbial lipid production, including nutritionally valuable polyunsaturated fatty acids. Hawaiian soils, shaped by volcanic parent materials and strong environmental gradients, provide a unique setting for discovering functionally diverse fungal strains with distinct metabolic traits.
Yu Wang, Adam Phelps, Zhiqing Fang, Qian Li, Ty Shitanaka, Taren Bouwman, Luke H. Amerine, Abigail Rohy, Kyla Mei A. Tuazon, Zhiyue Wang, Samir Kumar Khanal, Nhu Nguyen, Zhi‐Yan Du   +12 more
wiley   +1 more source

BRAIN-TIME: Testing Whether Prospective Recovery Position Modifies the Benefit of the Same Intervention in Addiction. [PDF]

Brain Sci
Makarewicz A, Recław R, Grzywacz A, Chmielowiec K, Jaworski Ł, Kuczak-Wójtowicz M, Chmielowiec J.   +6 more
europepmc   +1 more source

Nacre‐inspired layered composite with excellent mechanical support and osteogenic potential for cervical interbody cage

BMEMat, EarlyView.
The cervical interbody cage needs to take both biomechanical and biological requirements into account. Here, a new‐style degradable, multicomponent, and bioinspired nacre‐like cervical interbody cage composite, which exhibits promising mechanical‐support‐related behavior and osteogenesis‐related potential, is designed and prepared.
Xiu‐Wu Guo, Shao‐Meng Wen, Tian‐Yu Xing, Yang Zhou, Chun‐Xin Wang, Chang Ge, Si‐Ming Chen, Wen‐Zhi Zhang, Shu‐Hong Yu   +8 more
wiley   +1 more source

Structure-based molecular modeling of a novel S-Remiketamine scaffold and derived arylcyclohexanone analogues: NMDA receptor dynamics, MM-GBSA ranking, and CES1-Oriented structural compatibility. [PDF]

Front Chem
Alkhatip AAAMM, Raza U, Farag E, Hamza MK, Hosny H, Sallam A, Farag AMG, Wagih M, Naguib A, Abdulmegid AM, Algameel H, Bahr MH.   +11 more
europepmc   +1 more source

Substrate stiffness regulates cell fate and its applications in the repair of motor system: From two dimensions to three dimensions

BMEMat, EarlyView.
Substrate stiffness with different dimensions (2D and 3D) exerts a regulatory role in cellular behaviors, thereby governing cell fate decisions. Biomaterials with tunable stiffness exhibit substantial functional potential for the repair and regeneration of the motor system.
Zhiyuan Lu, Renwang Sheng, Ludvig J. Backman, Chuanquan Liu, Danning Zheng, Wei Zhang, Jialin Chen   +6 more
wiley   +1 more source