Results 91 to 100 of about 785,141 (269)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

High-Speed Flight Vehicle Strong Interference Data-Driven Control Based on Self-Organizing Map and Improved Moth-Flame Optimization

Aerospace
Owing to their reliance on detailed mathematical modeling, traditional control methods encounter challenges such as high control complexity and low precision when applied to high-speed flight vehicle control under strongly disturbed atmospheric ...
Chenghao Wang, Kaiqiang Feng, Jie Li, Li Qin, Xi Zhang, Junlong Li, Songhao Zhang, Yanchun Suo   +7 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Underground coal-rock image recognition using Swin-UNet with agent attention mechanism

Meitan kexue jishu
To address the challenges of coal-rock image segmentation under complex underground mining conditions—such as low illumination, high noise, and motion blur—this paper proposes an improved semantic segmentation model named Agent Swin-UNet, which ...
Chuanmeng SUN, Bin JIAO, Yiyan FU, Yuxiang WU, Yu WANG, Wenbo WANG, Yong LI   +6 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A Deep Regression Model for Tongue Image Color Correction Based on CNN

Journal of Imaging
Different viewing or shooting situations can affect color authenticity and generally lead to visual inconsistencies for the same images. At present, deep learning has gained popularity and opened up new avenues for image processing and optimization.
Xiyuan Cao, Delong Zhang, Chunyang Jin, Wei Zhang, Zhidong Zhang, Chenyang Xue   +5 more
doaj   +1 more source

Simultaneous localization and mapping in a multi-robot system in a dynamic environment with unknown initial correspondence. [PDF]

Front Robot AI, 2023
Malakouti-Khah H, Sadeghzadeh-Nokhodberiz N, Montazeri A.   +2 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Single-Mode Capability Enhancement of Curved Sapphire Fiber Utilizing High-Order Mode Suppression Characteristics Applied at High Temperature

Micromachines
In this paper, a comprehensive investigation into the single-mode capability of curved sapphire fiber is performed, ranging from theoretical simulation to experimental verification.
Fan He, Chengkuo Lee, Xiaojin Zhang, Jiamin Chen, Yongqiu Zheng, Chenyang Xue   +5 more
doaj   +1 more source