Results 91 to 100 of about 8,751,367 (357)

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Improved Kneser-type oscillation criterion for half-linear dynamic equations on time scales

AIMS Mathematics
We study the Kneser-type oscillation criterion for a class of second-order half-linear functional dynamic equations on an arbitrary time scale utilizing the integral averaging approach and the Riccati transformation method.
Taher S. Hassan, Amir Abdel Menaem , Hasan Nihal Zaidi, Khalid Alenzi, Bassant M. El-Matary   +4 more
doaj   +1 more source

Differential Equations Compatible with KZ Equations [PDF]

arXiv, 2000
We define a system of "dynamical" differential equations compatible with the KZ differential equations. The KZ differential equations are associated to a complex simple Lie algebra $\mathbf{g}$. These are equations on a function of $n$ complex variables $z_i$ taking values in the tensor product of $n$ finite dimensional $\mathbf{g}$-modules.
arxiv  

Hybrid simulations of lateral diffusion in fluctuating membranes

, 2006
In this paper we introduce a novel method to simulate lateral diffusion of inclusions in a fluctuating membrane. The regarded systems are governed by two dynamic processes: the height fluctuations of the membrane and the diffusion of the inclusion along ...
Ellen Reister-Gottfried, F. Brochard, G. Orädd, H. Risken, J. Lippincott-Schwartz, M. Doi, P. Schwartz, S. A. Safran, Stefan M. Leitenberger, T. Kohl, Udo Seifert, W. Helfrich   +11 more
core   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

Molecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld, Stefan Kühberger, Ricarda Graf, Christine Beichler, Markus Braun, Nadia Dandachi, Ellen Heitzer, Gerald W. Prager   +7 more
wiley   +1 more source

Necessary Condition for an Euler-Lagrange Equation on Time Scales

Abstract and Applied Analysis, 2014
We prove a necessary condition for a dynamic integrodifferential equation to be an Euler-Lagrange equation. New and interesting results for the discrete and quantum calculus are obtained as particular cases. An example of a second order dynamic equation,
Monika Dryl, Delfim F. M. Torres
doaj   +1 more source

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

Molecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda, Marina Reguero, Vanesa Abón, Marta Puyol   +3 more
wiley   +1 more source

Dynamic Evolution Equations for Isolated Smoke Vortexes in Rational Mechanics [PDF]

arXiv, 2011
Smoke circle vortexes are a typical dynamic phenomenon in nature. The similar circle vortexes phenomenon appears in hurricane, turbulence, and many others. A semi-empirical method is constructed to get some intrinsic understanding about such circle vortex structures.
arxiv  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source