Results 111 to 120 of about 1,353,777 (291)

Qualitative analysis of dynamic equations on time scales

open access: yes, 2018
In this article, we establish the Picard-Lindelof theorem and approximating results for dynamic equations on time scale. We present a simple proof for the existence and uniqueness of the solution.
Abbas, Syed
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Nonlinear triple-point problems on time scales

open access: yesElectronic Journal of Differential Equations, 2004
We establish the existence of multiple positive solutions to the nonlinear second-order triple-point boundary-value problem on time scales, $$displaylines{ u^{Delta abla}(t)+h(t)f(t,u(t))=0, cr u(a)=alpha u(b)+delta u^Delta(a),quad eta u(c)+gamma u^Delta(
Douglas R. Anderson
doaj  

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Parameter identification for gompertz and logistic dynamic equations. [PDF]

open access: yesPLoS One, 2020
Akın E, Pelen NN, Tiryaki IU, Yalcin F.
europepmc   +1 more source

Estimating unsteady aerodynamic forces on a cascade in a three-dimensional turbulence field [PDF]

open access: yes
An analytical method has been developed to estimate the unsteady aerodynamic forces caused by flow field turbulence on a wind tunnel turning vane cascade system (vane set).
Johnson, W., Norman, T.
core   +1 more source

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Motion of rock masses on slope

open access: yesGeologija, 2006
This paper shows the different ways of how rock masses (stones, rocks, and blocks) move along slopes and for each different way of motion (free fall, bouncing, rolling, sliding, slowing down, lubrication, fluidization)adequatedynamicequationsaregiven ...
Urška Petje   +2 more
doaj  

Advanced control concepts [PDF]

open access: yes
The selection of a trim solution that provides the space shuttle with the highest level of performance and dynamic control in the presense of wind disturbances and bias torques due to misalignment of rocket engines is described.
Friedland, B., Hutton, M. F.
core   +1 more source

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