Results 81 to 90 of about 4,336,710 (302)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dynamic Structural Equation Models

Structural Equation Modeling: A Multidisciplinary Journal, 2017
This article presents dynamic structural equation modeling (DSEM), which can be used to study the evolution of observed and latent variables as well as the structural equation models over time. DSEM is suitable for analyzing intensive longitudinal data where observations from multiple individuals are collected at many points in time.
Asparouhov, T., Hamaker, E.L., Muthen, Bengt   +2 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stability radii for linear time-varying differential–algebraic equations with respect to dynamic perturbations

, 2006
This paper is concerned with the robust stability for linear time-varying differential–algebraic equations. We consider the systems under the effect of uncertain dynamic perturbations. A formula of the structured stability radius is obtained.
Vu Hoang Linh, Nguyen Huu Du, Du N.H., Linh V.H.   +3 more
core   +1 more source

Iterative Kneser-Type Criteria for Oscillation of Half-Linear Second-Order Advanced Dynamic Equations

Mathematics
This work aims to develop new iterative Kneser-type criteria for determining the oscillatory behaviour of half-linear second-order advanced dynamic equations on arbitrary unbounded-above time scales T. The results extend and refine previously established
Taher S. Hassan, Bassant M. El-Matary, Ioan-Lucian Popa, Mouataz Billah Mesmouli, Ismoil Odinaev, Yousef Jawarneh   +5 more
doaj   +1 more source

Retraction Note: Ocean dynamic equations with the real gravity. [PDF]

Sci Rep, 2022
Chu PC.
europepmc   +1 more source

Dynamics of the McKean-Vlasov Equation

The Annals of Probability, 1994
The author goes on studying the limiting case of Dyson's model of the motion of eigenvalues of random symmetric matrices. The resulting Wiener- Hopf type flow -- described by the McKean-Vlasov equation -- is solved without making use of Wiener-Hopf theory.
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Existence of solutions to n-th order neutral dynamic equations on time scales

Electronic Journal of Differential Equations, 2010
In this article, we study n-th order neutral nonlinear dynamic equation on time scales. We obtain sufficient conditions for the existence of non-oscillatory solutions by using fixed point theory.
Qiaoluan Li, Zhenguo Zhang
doaj