Results 81 to 90 of about 1,353,777 (291)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Iterative Kneser-Type Criteria for Oscillation of Half-Linear Second-Order Advanced Dynamic Equations

Mathematics
This work aims to develop new iterative Kneser-type criteria for determining the oscillatory behaviour of half-linear second-order advanced dynamic equations on arbitrary unbounded-above time scales T. The results extend and refine previously established
Taher S. Hassan, Bassant M. El-Matary, Ioan-Lucian Popa, Mouataz Billah Mesmouli, Ismoil Odinaev, Yousef Jawarneh   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Existence of solutions to n-th order neutral dynamic equations on time scales

Electronic Journal of Differential Equations, 2010
In this article, we study n-th order neutral nonlinear dynamic equation on time scales. We obtain sufficient conditions for the existence of non-oscillatory solutions by using fixed point theory.
Qiaoluan Li, Zhenguo Zhang
doaj  

Retraction Note: Ocean dynamic equations with the real gravity. [PDF]

Sci Rep, 2022
Chu PC.
europepmc   +1 more source

Aeroelastic equations of motion of a Darrieus vertical-axis wind-turbine blade [PDF]

The second-degree nonlinear aeroelastic equations of motion for a slender, flexible, nonuniform, Darrieus vertical-axis wind turbine blade which is undergoing combined flatwise bending, edgewise bending, torsion, and extension are developed using ...
Kaza, K. R. V., Kvaternik, R. G.
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Dynamic Landau-Lifshitz-Bloch-Slonczewski equations for spintronics [PDF]

AIP Advances
The atomistic Landau-Lifshitz-Gilbert equation is challenged when modeling spintronic devices where Joule heating is significant, due to its core assumption of a constant magnetization magnitude.
Pascal Thibaudeau, Mouad Fattouhi, Liliana D. Buda-Prejbeanu   +2 more
doaj   +1 more source