Results 41 to 50 of about 5,413 (299)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Dynamic Fault Tree Based on Weibull Distribution
, 2011 The fault tree analysis is a widely used method for evaluation of systems reliability and safety. Dynamic fault tree (DFT) extend traditional FT by defining additional gates called dynamic gates to model these complex interactions. Markov models are used
Shu Yan Liu, Wei Gang Guo, Wei Han
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DFT analysis of Ship pilotage risk based on A.D. Hall models
MATEC Web of Conferences, 2017 Based on A pilot station more than 10 years of pilotage safety accident database, from three angles, including time, link and space, the statistical of ship pilotage safety accident risk is analysis, from which obtain the pilotage safety accident ...
hongbin Wei
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Optimal Maintenance Management of Offshore Wind Farms
Energies, 2016 Nowadays offshore wind energy is the renewable energy source with the highest growth. Offshore wind farms are composed of large and complex wind turbines, requiring a high level of reliability, availability, maintainability and safety (RAMS).
Alberto Pliego Marugán +2 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Analysis on Dynamic Fault Tree Based on Fuzzy Set
, 2011 In case of fault tree analysis of large complex system, the probability of bottom event in dynamic fault tree is uncertain in some cases. To address the problem, the paper presented a dynamic fault tree analysis method based on fuzzy set computation. The
Li Ping Yang
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Hangkong gongcheng jinzhan, 2023 The existing technologies are difficult to identify the airborne software faults and the corresponding causes, and thus cannot be applied in the development process of the airborne software, so the airborne software fault modeling and analysis technique ...
WEN Xiaoling +3 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
机车电传动, 2020 A highly reliable ladder redundant structure networking scheme applied to train communication network was constructed, and the fault protection and redundant switching mechanism of the network were analyzed.
Tao GUO +4 more
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