Results 91 to 100 of about 983,585 (327)
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Exploring Dynamic Characteristics of Multi-State Air Traffic Flow: A Time Series Approach [PDF]
, 2020 Shanmei Li, Wang Chao, Wang Jing
openalex +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Dynamic flows create potentially habitable conditions in Antarctic subglacial lakes. [PDF]
Sci Adv, 2021 Couston LA, Siegert M.
europepmc +1 more source
Several comments concerning a recently proposed magnetospheric model [PDF]
Magnetospheric model for dynamic plasma flows in polar ...
Frank, L. A.
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Local similarity and velocity distribution in turbulent flows
Инженерно-строительный журнал, 2012 Justification of conditions for similarity of turbulent flows cinematic and dynamic characteristics is fundamental for solving the hydraulic modeling problems and calculating the water supply and sewerage systems, culverts in hydraulic and highway ...
V.S. Borovkov +3 more
doaj
Journal of Information and TelecommunicationWe develop a dynamic Quality of Service (QoS) routing algorithm based on network traffic prediction for Sixth Generation (6G) SDNs. First, we formulate a mixed integer optimization model that incorporates the key constraints for Ultra-Reliable Low ...
Buse Pehlivan +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source