Results 161 to 170 of about 12,139,664 (308)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

The dynamic impact behavior of the human neurocranium. [PDF]

open access: yesSci Rep, 2021
Zwirner J   +5 more
europepmc   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

Fostering Impactful Careers: A Tool for Reflection

open access: yes
Our EUR strategic priorities of Creating Positive Societal Impact and Recognition & Rewards mean that we increasingly support those who are passionate about creating and fostering positive societal impact.
Evaluating Societal Impact
core   +1 more source

Experiment and Numerical Simulation on the Damage to the Cement Sheath during Shaped Perforation

open access: yesShiyou jixie, 2019
There are few studies on the damage of the cement sheath under dynamic impact load of the shaped perforation. In view of this, taking the damage of cement sheath by the impact of shaped perforation as study object, the perforating test under temperature ...
Han Yaotu   +5 more
doaj  

Dynamic impact of liver allocation policy change on donor utilization. [PDF]

open access: yesAm J Transplant, 2022
Chan E   +6 more
europepmc   +1 more source

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