Results 171 to 180 of about 36,870 (217)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

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Stochastic Dynamics of Impact Oscillators

Journal of Applied Mechanics, 2004
Abstract The purpose of this work is to develop an averaging approach to study the dynamics of a vibro-impact system excited by random perturbations. As a prototype, we consider a noisy single-degree-of-freedom equation with both positive and negative stiffness and achieve a model reduction, i.e., the development of rigorous methods to ...
Namachchivaya, N. Sri, Park, Jun H.
openaire   +2 more sources

The Impact of Viscosity on the DNA Dynamics

Physica Scripta, 2001
Summary: We investigate the nonlinear dynamics of a DNA chain affected by the damping associated with the viscosity of a solvent. The dynamics of the DNA chain is described by the Peyrard-Bishop [\textit{M. Peyrard} and \textit{A. R. Bishop}, Phys. Rev. Lett. 62, 2755 ff (1989)] extended model for breather-like coherent excitations. We show that a bell
Zdravković, S., Satarić, M. V.
openaire   +1 more source

The Impact Dynamics

2010
Together with geological/geophysical studies and laboratory-scale experiments numerical simulations of impacts contribute a great deal to our knowledge of the cratering process. Whereas field studies give information about target conditions and final crater configuration, numerical modeling allow us to follow the evolving process in time and to ...
Valery Shuvalov, Henning Dypvik, Filippos Tsikalas   +2 more
openaire   +1 more source

An Investigation of the Dynamic System with Impacts

Chaos, Solitons & Fractals, 1998
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Błażejczyk-Okolewska, Barbara, Peterka, František   +1 more
openaire   +1 more source

Schizophrenia: Impact on Family Dynamics

Current Psychiatry Reports, 2017
In many societies, family members are now the primary caregivers of mental health patients, taking on responsibilities traditionally under the purview of hospitals and medical professionals. The impact of this shift on the family is high, having both an emotional and economic toll.
Caqueo-Urízar, Alejandra, Rus-Calafell, Mar, Craig, Thomas K.J., Irarrazaval, Matias, Urzúa, Alfonso, Boyer, Laurent, Williams, David R.   +6 more
openaire   +3 more sources

Impact Dynamics for Elastic Membranes

Physical Review Letters, 2006
We study the dynamic response of stretched thin polymeric films following an impact by a rigid sphere. We vary the sphere radius, the impact velocity, and the film tension, and measure the contact time and the maximum deflection of the film during the impact. The response is sensitive to nonlinearities associated with the additional tension provided by
Laurent, Courbin, Antonin, Marchand, Ashkan, Vaziri, Armand, Ajdari, Howard A, Stone   +4 more
openaire   +2 more sources

Revealing the dynamics of a large impact

Science, 2016
Drilling into the Chicxulub crater provides constraints on how it ...
openaire   +2 more sources