Results 181 to 190 of about 12,139,664 (308)

Fracture-based grasping: dynamic impact enables predictable robotic anchoring to freshwater ice. [PDF]

Npj Robot
Galassi A, Trebi-Ollennu A, Papadopoulos P, Stuart HS.   +3 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A Dynamic Impact Simulation Method for Titanium-Based Functionally Graded Composites Based on Abaqus/Explicit: Parametric Analysis, Mesh Strategy, Numerical Artifact Mitigation, and CAE Modeling. [PDF]

Materials (Basel)
Shao X, Wang W, Xie J, Li B, Mao Z.
europepmc   +1 more source

Dynamic impact of virome on colitis and colorectal cancer: Immunity, inflammation, prevention and treatment. [PDF]

Semin Cancer Biol, 2022
Wang Z, Guo K, Liu Y, Huang C, Wu M.
europepmc   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The spatial and dynamic impact of air pollution on public health: Evidence from China 2000-2021. [PDF]

PLoS One
Qin Y, Lin X, Duan Y.
europepmc   +1 more source

Unbundling the dynamic impact of renewable energy and financial development on real per capita growth in African countries. [PDF]

Environ Sci Pollut Res Int, 2023
Konyeaso AW, Eregha PB, Vo XV.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Dynamic impact of bivalent COVID-19 vaccine boosters on systemic and mucosal antibody and T cell immunity. [PDF]

Sci Rep
Kronsteiner B, Govender M, Liu C, Dijokaite-Guraliuc A, Ali M, Hill J, Zewdie M, Cross A, Austin J, Watts A, Angyal A, Hornsby H, Abraham P, Adele S, Moulik S, Harte J, Hargreaves A, Jiwa Y, Selvaraj M, Stafford L, Jamsen A, Dobson SL, Sampaio S, Halstead C, Steel A, Longet S, Faustini SE, Moore SC, Mongkolsapaya J, Wootton DG, Thaventhiran JED, Hopkins S, Hall V, Jeffery K, Barnes E, Duncan CJA, Payne RP, Richter AG, de Silva TI, Turtle L, Screaton GR, Klenerman P, Carroll M, Dunachie SJ, PITCH Consortium.   +44 more
europepmc   +1 more source

The Dynamic Impact of the COVID-19 Pandemic on Air Quality: The Beijing Lessons. [PDF]

Int J Environ Res Public Health, 2021
Tao C, Diao G, Cheng B.
europepmc   +1 more source