Results 91 to 100 of about 358,015 (308)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The dynamic kinetochore-microtubule interface [PDF]

Journal of Cell Science, 2004
The kinetochore is a control module that both powers and regulates chromosome segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably fluid, with the microtubules growing and shrinking at their point of attachment to the kinetochore.
Maiato, H, DeLuca, J, Salmon, ED, Earnshaw, WC   +3 more
openaire   +3 more sources

The Measurement and Analysis of the Disc/Pad Interface Dynamic Centre of Pressure and its Influence on Brake Noise. [PDF]

, 2008
This paper discusses the measurement of the dynamic centre of pressure (CoP) of a brake pad during a normal braking event using a modified 12-piston opposed calliper. The modifications allow the centre of pressure to be controlled both radially and along
John D. Fieldhouse, Talbot, Chris J., Fieldhouse, John D., Chris Talbot, Ashraf, Naveed, Naveed Ashraf   +5 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Numerical Modeling of Fluid Flow, Heat Transfer and Arc–Melt Interaction in Tungsten Inert Gas Welding

High Temperature Materials and Processes, 2017
The present work develops a multi-region dynamic coupling model for fluid flow, heat transfer and arc–melt interaction in tungsten inert gas (TIG) welding using the dynamic mesh technique.
Li Linmin, Li Baokuan, Liu Lichao, Motoyama Yuichi   +3 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Efficient Collision Detection While Rendering Dynamic Point Clouds [PDF]

, 2014
A recent trend in interactive environments is the use of unstructured and temporally varying point clouds. This is driven by both affordable depth cameras and augmented reality simulations.
Ohrhallinger, Stefan, Wimmer, Michael, Radwan, Mohamed   +2 more
core  

Real-time, all-frequency shadows in dynamic scenes [PDF]

, 2008
Shadow computation in dynamic scenes under complex illumination is a challenging problem. Methods based on precomputation provide accurate, real-time solutions, but are hard to extend to dynamic scenes.
Seidel, Hans-Peter, Tom Mertens, Hans-Peter Seidel, Mertens, T., Kautz, J, Dong, Zhao, Kautz, Jan, Kautz, J., Seidel, HP, Dong, Z, Bekaert, P, Bekaert, P., Mertens, Tom, Seidel, H. ; https://orcid.org/, Zhao Dong, Thomas Annen, Annen, T, Philippe Bekaert, Jan Kautz, Bekaert, Philippe, Annen, T., Seidel, P, Dong, Z., Mertens, T, Annen, Thomas   +24 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Response of Thermoelastic Micropolar Cubic Crystal under Dynamic Load at an Interface

International Journal of Applied Mechanics and Engineering, 2017
The purpose of this paper is to study the two dimensional deformation in a thermoelastic micropolar solid with cubic symmetry. A mechanical force is applied along the interface of a thermoelastic micropolar solid with cubic symmetry (Medium I) and a ...
P. Ailawalia, S.K. Sachdeva, D. Pathania
doaj   +1 more source