Results 31 to 40 of about 1,552 (250)

A Tour Recommendation System Considering Implicit and Dynamic Information

Applied Sciences
Tourism has become one of the world’s largest service industries. Due to the rapid development of social media, more people like self-guided tours than package itineraries planned by travel agencies.
Chieh-Yuan Tsai, Kai-Wen Chuang, Hen-Yi Jen, Hao Huang   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Edge-Enhanced Federated Optimization for Real-Time Silver-Haired Whirlwind Trip

Tourism and Hospitality
We propose an edge-enhanced federated learning framework for real-time itinerary optimization in elderly oriented adventure tourism, addressing the critical need for adaptive scheduling that balances activity intensity with health constraints. The system
Xiaolong Chen, Hongfeng Zhang, Cora Un In Wong, Hongbo Ge   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Optimizing group utility in itinerary planning: a strategic and crowd-aware approach

Journal of Big Data
Itinerary recommendation is a complex sequence prediction problem with numerous practical applications. The task becomes significantly more challenging when optimizing multiple factors simultaneously, such as user queuing times, crowd levels, attraction ...
Junhua Liu, Aldy Gunawan, Kristin L. Wood, Kwan Hui Lim   +3 more
doaj   +1 more source

Deep learning based real-time tourist spots detection and recognition mechanism

Science Progress, 2021
More and more information on tourist spots is being represented as pictures rather than text. Consequently, tourists who are interested in a specific attraction shown in pictures may have no idea how to perform a text search to get more information about
Yen-Chiu Chen, Kun-Ming Yu, Tzu-Hsiang Kao, Hao-Lun Hsieh   +3 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Il territorio raccontato: la valorizzazione dei ‘luoghi’ di Ignazio Silone come elemento propulsivo di circuiti geoturistici autosostenibili

Scienze del Territorio, 2018
Literary routes inspired by landscapes can become key elements for a self-sustainable development, they illuminating the collective memory, encouraging grassroots processes of self-organisation, and highlighting the relationships between the growth of ...
Annalisa Colecchia
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source