Results 41 to 50 of about 34,236 (270)

Guidebook use by Japanese tourists: a qualitative study of Australia inbound travellers [PDF]

open access: yes, 2006
This qualitative investigation into guidebook use reports on in-depth interviews conducted with 26 Japanese individuals and one couple who had visited Australia during the five previous years.
King, Brian   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Deep learning based real-time tourist spots detection and recognition mechanism

open access: yesScience Progress, 2021
More and more information on tourist spots is being represented as pictures rather than text. Consequently, tourists who are interested in a specific attraction shown in pictures may have no idea how to perform a text search to get more information about
Yen-Chiu Chen   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Optimizing group utility in itinerary planning: a strategic and crowd-aware approach

open access: yesJournal of Big Data
Itinerary recommendation is a complex sequence prediction problem with numerous practical applications. The task becomes significantly more challenging when optimizing multiple factors simultaneously, such as user queuing times, crowd levels, attraction ...
Junhua Liu   +3 more
doaj   +1 more source

Renormalization theory for multimodal maps

open access: yes, 2001
We study the dynamics of the renormalization operator for multimodal maps. In particular, we prove the exponential convergence of this operator for infinitely renormalizable maps with same bounded combinatorial type.Comment: 37 pages, 4 ...
Smania, Daniel
core   +3 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Il territorio raccontato: la valorizzazione dei ‘luoghi’ di Ignazio Silone come elemento propulsivo di circuiti geoturistici autosostenibili

open access: yesScienze del Territorio, 2018
Literary routes inspired by landscapes can become key elements for a self-sustainable development, they illuminating the collective memory, encouraging grassroots processes of self-organisation, and highlighting the relationships between the growth of ...
Annalisa Colecchia
doaj   +1 more source

Optimizing Computation of Recovery Plans for BPEL Applications

open access: yes, 2010
Web service applications are distributed processes that are composed of dynamically bounded services. In our previous work [15], we have described a framework for performing runtime monitoring of web service against behavioural correctness properties ...
Gwen Salaün   +5 more
core   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

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