Results 51 to 60 of about 214 (207)

A New Framework for Centralized Coordinated Multi-Vehicle Dynamic Routing

IEEE Access
In the context of rapid urbanization, the problem of long travel times has become a significant problem for contemporary cities, both socially and economically.
M. D. R. L. Silva, M. Tang
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A multi model orchestrated agent for live flight and hotel itinerary generation

Discover Artificial Intelligence
The evolution of large language models into autonomous, goal-oriented systems capable of advanced reasoning, contextual memory recall, and dynamic tool orchestration is referred to as agentic AI. This work introduces an intelligent travel companion built
B. Nethravathi, Pooja Gupta, C. P. Lalitha Shree, S. Srivatsa, G. N. Harshith, Sudharani   +5 more
doaj   +1 more source

A Multi-Agent Approach for Reactionary Delay Prediction of Flights

IEEE Access, 2019
Flight schedules are highly sensitive to delays and witness these events on a very frequent basis. In an interconnected and interdependent air transportation system, these delays can magnify and cascade as the flight itineraries progress, causing ...
Yash Guleria, Qing Cai, Sameer Alam, Lishuai Li   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

GLMI: An Efficient Spatiotemporal Index Leveraging Geohash and Piecewise Linear Models for Optimized Query Performance

Algorithms
Spatiotemporal big data contain information in multiple dimensions such as space and time. Spatiotemporal data have the characteristics of large volume, intricate spatiotemporal relationship, and uneven spatiotemporal distribution. Index structure is one
Kun Chen, Gang Liu, Genshen Chen, Zhengping Weng, Qiyu Chen   +4 more
doaj   +1 more source

A dynamic model for optimising fare inspector itineraries in public transport networks

Transportation
Abstract Fare evasion, defined as the act of using public transport without paying the required fare, poses a significant challenge to the financial viability of public transport systems. Fare inspection is accordingly employed as a key control mechanism to verify that passengers have paid the appropriate fare for their journey ...
Tianwei Yin, Neema Nassir, Hidi Ghaderi, Egemen Tanin   +3 more
openaire   +1 more source