Results 61 to 70 of about 122,033 (316)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Meitan kexue jishuThe stress environment of deep coal-rock mass is complex, to further reveal the mechanism of rock burst induced by dynamic load. Based on the Split Hopkinson Pressure Bar test system, the dynamic tests under different stress states (non-axial and ...
Zhihui MA +3 more
doaj +1 more source
Nonlinear equations of ribbed shells motion taking into account the different properties of the material. II [PDF]
Инженерно-строительный журнал, 2010 It is known that in the process of deformation of shells depending on the level and duration of external influences may appear different properties of the material of construction: elasticity, plasticity, creep, etc.
V.M. Zhgutov
doaj
Integral assessment of stress-defomated condition of metal structures of machines under the action of static and dynamic loads [PDF]
, 2021 Іван Назаренко +4 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Optimization of Bridge Crane Movement Control
Наука и техника, 2018 Transient modes of bridge cranes movement determine their energy, dynamic and electrical performance, as well as productivity and durability of work. An optimal control problem of its movement has been solved while making an analysis of indicators for ...
V. S. Loveikin, Y. A. Romasevich
doaj +1 more source
Dynamic Load Balancing with Tokens [PDF]
2018 IFIP Networking Conference (IFIP Networking) and Workshops, 2018 Efficiently exploiting the resources of data centers is a complex task that requires efficient and reliable load balancing and resource allocation algorithms. The former are in charge of assigning jobs to servers upon their arrival in the system, while the latter are responsible for sharing server resources between their assigned jobs. These algorithms
openaire +3 more sources
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Intervertebral Disc‐on‐a‐ChipMF: A New Model for Mouse Disc Culture via Integrating Mechanical Loading and Dynamic Media Flow (Adv. Mater. Technol. 21/2023) [PDF]
, 2023 Wanqing Xie +14 more
openalex +1 more source