Results 71 to 80 of about 137,150 (318)
Capturing the Dynamics of a Spring-Loaded Protein [PDF]
Structure, 2017 Skp and other holdase chaperones bind unfolded bacterial outer membrane proteins, preventing premature folding until they insert into the membrane. In this issue of Structure, Holdbrook et al. (2017) use a combination of NMR, SAXS, ensemble optimization, and MD simulations to show that the Skp chaperone samples a much wider range of conformations than ...
Mitchell, Joshua, O'Mara, Megan
openaire +5 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Experimental evaluation of load transfer efficiency of non-dowelled concrete pavements
Građevinar, 2022 Generally, joint performance in concrete pavements is evaluated in laboratory by applying dynamic loads that require large scale experimental setups. In order to propose a simplified laboratory test, a comprehensive literary review of the fundamentals of
Mauricio Pradena +2 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
ABOUT DYNAMIC LOADS REDUCTION IN THE DRIVE TO THE CAMSHAFT OF THE FUEL PUMP OF TRANSPORT DIESEL [PDF]
Avtomobilʹnyj Transport (Harʹkov), 2018 Problem. The power and speed increase of modern internal combustion engines (ICE) leads to increasing of dynamic loads in power transmissions of machine units.
Shatokhin V., Granko B., Sobol V.
doaj +1 more source
Dynamic Loadings Of Precastretaining Walls
Kirkuk University Journal-Scientific Studies, 2007 The research aims for the selection of a suitable retaining wall amongst two types of precast concrete walls under dynamic loads (wave pressure). The first wall is of a triangular cross section and has the dimensions (3)m (in height) by (2.2) m (in width) by (0.25-0.3) m (in thickness) and the width of piece (1.44) m. The second wall has dimensions of (
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FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Dynamic load balancing with group communication
Theoretical Computer Science, 2006 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Shlomi Dolev +2 more
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The influence of pre-existing vibrations on the dynamic response of medium span bridges
, 2009 Critical static bridge loading scenarios are often expressed in terms of the number of vehicles that are present on the bridge at the time of occurrence of maximum lifetime load effect.
O'Brien, Eugene J. +2 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source