We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
In this work, a time–frequency analysis of two railway bridges included in the InBridge4EU project database is presented. The study focuses on the identification of modal parameters from free responses after train passages and their comparison with ...
Pedro Galvín +4 more
doaj +1 more source
Requirements for implementation of Kuessner and Wagner indicial lift growth functions into the FLEXSTAB computer program system for use in dynamic loads analyses [PDF]
General requirements for dynamic loads analyses are described. The indicial lift growth function unsteady subsonic aerodynamic representation is reviewed, and the FLEXSTAB CPS is evaluated with respect to these general requirements.
Miller, R. D., Rogers, J. T.
core +1 more source
Reliability of Dynamic Load Scheduling with Solar Forecast Scenarios
This paper presents and evaluates the performance of an optimal scheduling algorithm that selects the on/off combinations and timing of a finite set of dynamic electric loads on the basis of short term predictions of the power delivery from a ...
de Callafon, Raymond A. +4 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Vibroacoustic Analysis of The Hydrocarbon Processing Plant Piping System Operating at Elevated Temperature. [PDF]
In this paper it is presented the vibroacoustic analysis of the selected section of the hydrocarbon processing chemical plant piping system operating at elevated temperature and subjected to dynamic load exciting vibration of the structure.
Błaszczyk, Andrzej +3 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Vertical-plane pendulum absorbers for minimizing helicopter vibratory loads [PDF]
The use of pendulum dynamic absorbers mounted on the blade root and operating in the vertical plane to minimize helicopter vibratory loads was discussed.
Amer, K. B., Neff, J. R.
core +1 more source
Dynamic analysis of Apollo-Salyut/Soyuz docking [PDF]
The use of a docking-system computer program in analyzing the dynamic environment produced by two impacting spacecraft and the attitude control systems is discussed.
Schliesing, J. A.
core +1 more source

