Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Preliminary analysis of performance and loads data from the 2-megawatt mod-1 wind turbine generator [PDF]
Preliminary test data on output power versus wind speed, rotor blade loads, system dynamic behavior, and start-stop characteristics on the Mod-1 wind turbine generator are presented.
Neustadter, H. E. +3 more
core +1 more source
Dynamically Loading Mobile/Cloud Assemblies [PDF]
, 2017 Distributed applications that span mobile devices, computing clusters, and cloud services, require robust and flexible mechanisms for dynamically loading code. This paper describes lady: a system that augments the .net platform with a highly reliable mechanism for resolving and loading assemblies, and arranges for safe execution of partially trusted ...
Pettersen, Robert +3 more
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Mechanism and Practice of Multifracturing Using Dynamic Loads in a Low-Permeability Coal Reservoir. [PDF]
ACS Omega, 2023 Qi Y +6 more
europepmc +1 more source
Influence of linear profile modification and loading conditions on the dynamic tooth load and stress of high contact ratio gears [PDF]
A computer simulation for the dynamic response of high-contact-ratio spur gear transmissions is presented. High contact ratio gears have the potential to produce lower dynamic tooth loads and minimum root stress but they can be sensitive to tooth profile
Lee, Chinwai +3 more
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Could Horse Gait and Induced Pelvic Dynamic Loads in Female Equestrians Be a Risk Factor in Pudendal Neuralgia? [PDF]
Sports (Basel), 2023 Murer S +5 more
europepmc +1 more source
A multi-purpose method for analysis of spur gear tooth loading [PDF]
A large digitized approach was developed for the static and dynamic load analysis of spur gearing. An iterative procedure was used to calculate directly the "variable-variable" gear mesh stiffness as a function of transmitted load, gear tooth profile ...
August, R. +3 more
core +1 more source
Simplified Algorithm for Dynamic Demand Response in Smart Homes Under Smart Grid Environment
, 2019 Under Smart Grid environment, the consumers may respond to incentive--based smart energy tariffs for a particular consumption pattern. Demand Response (DR) is a portfolio of signaling schemes from the utility to the consumers for load shifting/shedding ...
Namboodiri, Aryesh +2 more
core +1 more source