Results 71 to 80 of about 26,531,310 (313)
Multiregression Dynamic Models
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1993 SUMMARY Multiregression dynamic models are defined to preserve certain conditional independence structures over time across a multivariate time series. They are non-Gaussian and yet they can often be updated in closed form. The first two moments of their one-step-ahead forecast distribution can be easily calculated. Furthermore, they can
Queen, Catriona M., Smith, Jim Q.
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Jurnal Penelitian dan Pembelajaran IPA, 2018 Integration of dynamic and static modeling on guided inquiry learning can help students to understand chemical concepts at macroscopic, symbolic and microscopic levels.
Indah Langitasari +2 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
On a Dynamical Model of Glasses [PDF]
Journal de Physique I, 1995 We analyze a simple dynamical model of glasses, based on the idea that each particle is trapped in a local potential well, which itself evolves due to hopping of neighbouring particles. The glass transition is signalled by the fact that the equilibrium distribution ceases to be normalisable, and dynamics becomes non-stationary.
Bouchaud, Jean-Philippe +2 more
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A Novel Dual-Motor Two-Speed Direct Drive Battery Electric Vehicle Drivetrain
IEEE Access, 2019 Although the demand of battery electric vehicle (BEV) growths fast as the requirement of reducing greenhouse gas emission and the usage of fossil fuels, the limited driving range and unfriendly retail price present barriers to BEV to provide comparable ...
Jiageng Ruan, Qiang Song
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Revista Transilvană de Ştiinţe Administrative, 2003 System Dynamics was introduced by Jay W. Forrester in the 1960s. Since then the methodology was adopted in many areas of natural or social sciences.
Sorin Dan ŞANDOR
doaj