Results 91 to 100 of about 2,018,771 (302)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Dynamic Systems Modeling

open access: yesRevista Transilvană de Ştiinţe Administrative, 2003
System Dynamics was introduced by Jay W. Forrester in the 1960s. Since then the methodology was adopted in many areas of natural or social sciences.
Sorin Dan ŞANDOR
doaj  

Nonlinear Modeling and Docking Tests of a Soft Modular Robot

open access: yesIEEE Access, 2019
Soft modular robots have the advantages of both bionic continuum robots and modular self-reconfigurable robots. They have potential application for working in narrow space and uneven terrain.
Yu Zhang   +5 more
doaj   +1 more source

Multiregression Dynamic Models

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 1993
SUMMARY Multiregression dynamic models are defined to preserve certain conditional independence structures over time across a multivariate time series. They are non-Gaussian and yet they can often be updated in closed form. The first two moments of their one-step-ahead forecast distribution can be easily calculated. Furthermore, they can
Queen, Catriona M., Smith, Jim Q.
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Monitoring Current Status of and Trends in Boreal Forest Land Use in Russian Karelia

open access: yesEcology and Society, 2003
Some of the last remaining near-natural boreal forest landscapes in northern Europe can be found in the Russian Karelia near its border with Finland.
Charles Burnett   +3 more
doaj   +1 more source

The dynamic analysis of submerged structures [PDF]

open access: yes, 1975
Methods are described by which the dynamic interaction of structures with surrounding fluids can be computed by using finite element techniques. In all cases, the fluid is assumed to behave as an acoustic medium and is initially stationary. Such problems
Everstine, G. C.   +2 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Variation in emotion dynamics over time is associated with future relationship outcomes

open access: yesFrontiers in Human Neuroscience
Romantic relationships are defined by emotion dynamics, or how the emotions of one partner at a single timepoint can affect their own emotions and the emotions of their partner at the next timepoint.
Simran K. Johal, Emilio Ferrer
doaj   +1 more source

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