Results 71 to 80 of about 3,963,463 (245)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dual population-based incremental learning for problem optimization in dynamic environments [PDF]

, 2003
Copyright @ 2003 Asia Pacific Symposium on Intelligent and Evolutionary SystemsIn recent years there is a growing interest in the research of evolutionary algorithms for dynamic optimization problems since real world problems are usually dynamic, which ...
Yang, S, Yao, X
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The dynamic nature of motivation in language learning: A classroom perspective

Studies in Second Language Learning and Teaching, 2012
When we examine the empirical investigations of motivation in second and foreign language learning, even those drawing upon the latest theoretical paradigms, such as the L2 motivational self system (Dörnyei, 2009), it becomes clear that many of them ...
Mirosław Pawlak
doaj   +1 more source

Evaluating the Dynamic Nature of Market Risk [PDF]

This study examines the systematic risk present in major crops for the United States and three corn-belt states. An index of commodities is used in conjunction with cash receipts to generate dynamic estimates of the systematic risk for each crop and ...
Baker, Timothy G., Hubbs, Todd, Kuethe, Todd H.   +2 more
core   +1 more source

On the quantum description of Einstein's Brownian motion

, 2004
A fully quantum treatment of Einstein's Brownian motion is given, showing in particular the role played by the two original requirements of translational invariance and connection between dynamics of the Brownian particle and atomic nature of the medium.
A. Einstein, A. Einstein, A. Griffin, A. S. Holevo, B. Vacchini, Bassano Vacchini, C. S. Wang Chang, E. Joos, F. Schwabl, Francesco Petruccione, G.-L. Ingold, H. P. Breuer, H. Spohn, L. Pitaevskii, N. W. Ashcroft, P. Busch, R. Brown, S. W. Lovesey, U. Weiss, V. Ambegaokar   +19 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Changes in sarcopenia and incident cardiovascular disease in prospective cohorts

BMC Medicine
Background Previous studies have identified sarcopenia as a significant risk factor for cardiovascular disease (CVD). However, these studies primarily focused on sarcopenia status at baseline, without considering changes in sarcopenia status during ...
Qingyue Zeng, Lijun Zhao, Qian Zhong, Zhenmei An, Shuangqing Li   +4 more
doaj   +1 more source

Home Range Size and Resource Use of Breeding and Non-breeding White Storks Along a Land Use Gradient

Frontiers in Ecology and Evolution, 2018
Biotelemetry is increasingly used to study animal movement at high spatial and temporal resolution and guide conservation and resource management.
Damaris Zurell, Henrik von Wehrden, Shay Rotics, Michael Kaatz, Helge Groß, Helge Groß, Lena Schlag, Merlin Schäfer, Merlin Schäfer, Nir Sapir, Sondra Turjeman, Martin Wikelski, Martin Wikelski, Ran Nathan, Florian Jeltsch, Florian Jeltsch   +15 more
doaj   +1 more source

The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

Anthropological Review, 2020
Ageing is one of the most complex and difficult problems for humans to face and for science to solve. Although human senescence was viewed as a passive and uncontrollable process of deterioration over time with little or no genetic regulation, the ...
Chmielewski Piotr Paweł
doaj   +1 more source