Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
Spatiotemporal Interactive Modeling of Event-based Dynamic Networks. [PDF]
TechnometricsWang D, Xian X, Li H.
europepmc +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Analysis of the SEIR mean-field model in dynamic networks under intervention. [PDF]
Infect Dis ModelLi J, Jin Z, Tang M.
europepmc +1 more source
Prediction of hospital-onset COVID-19 infections using dynamic networks of patient contact: an international retrospective cohort study. [PDF]
Lancet Digit Health, 2022 Myall A +14 more
europepmc +1 more source
In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols
FEBS Open Bio, EarlyView.Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton +6 more
wiley +1 more source
Dynamic networks connect the USP14 active site region with the proteasome interaction surface. [PDF]
Protein SciSalomonsson J +6 more
europepmc +1 more source
Dynamic networks of psychological symptoms, impairment, substance use, and social support: The evolution of psychopathology among emerging adults. [PDF]
Eur Psychiatry, 2022 Crouse JJ +12 more
europepmc +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Change and External Events in Computer-Mediated Citation Networks: English Language Weblogs and the 2004 U.S. Electoral Cycle [PDF]
Journal of Social Structure, 2009 Carter T. Butts, B. Remy Cross
doaj +1 more source