Results 41 to 50 of about 426,852 (266)
The minimum cost multicommodity flow problem in dynamic networks and an algorithm for its solving [PDF]
Computer Science Journal of Moldova, 2005 The dynamic version of the minimum cost multicommodity flow problem that generalizes the static minimum cost multicommodity flow problem is formulated and studied.
Maria A. Fonoberova, Dmitrii D. Lozovanu
doaj
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
AFE-Net: Attention-Guided Feature Enhancement Network for Infrared Small Target Detection
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingInfrared small target detection is considerably challenging due to the few pixels in targets, low signal-to-noise ratio, and complex background. In this article, we propose an effective attention-guided feature enhancement network (AFE-Net), which can ...
Keyan Wang +6 more
doaj +1 more source
Deep Learning for Link Prediction in Dynamic Networks Using Weak Estimators
IEEE Access, 2018 Link prediction is the task of evaluating the probability that an edge exists in a network, and it has useful applications in many domains. Traditional approaches rely on measuring the similarity between two nodes in a static context. Recent research has
Carter Chiu, Justin Zhan
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Public Goods Games on Coevolving Social Network Models
Frontiers in Physics, 2020 Public good games are a metaphor for modeling cooperative behavior in groups in the presence of incentives to free ride. In the model presented here agents play a public good game with their neighbors in a social network structure. Agents' decision rules
Marco Tomassini, Alberto Antonioni
doaj +1 more source
Sustainable network dynamics [PDF]
Ecological Modelling, 2011 We propose a dynamic graph-theoretic model for ecosystem management as a control over networked system composed of target nodes and unmarked nodes. The network is represented by a complete graph, in which all vertices are connected by a unique edge. Target nodes are attracted by the objective function issued from the ecosystem-based management.
Dragicevic, Arnaud, A. +1 more
openaire +6 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source