Results 51 to 60 of about 2,074,615 (279)

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

AFE-Net: Attention-Guided Feature Enhancement Network for Infrared Small Target Detection

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Infrared small target detection is considerably challenging due to the few pixels in targets, low signal-to-noise ratio, and complex background. In this article, we propose an effective attention-guided feature enhancement network (AFE-Net), which can ...
Keyan Wang, Xueyan Wu, Peicheng Zhou, Zuntian Chen, Rui Zhang, Liyun Yang, Yunsong Li   +6 more
doaj   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Smoothed Analysis of Dynamic Networks

, 2015
We generalize the technique of smoothed analysis to distributed algorithms in dynamic network models. Whereas standard smoothed analysis studies the impact of small random perturbations of input values on algorithm performance metrics, dynamic graph ...
A Das Sarma, C Avin, C Newport, DA Spielman, DA Spielman, DA Spielman, F Kuhn, O Denysyuk   +7 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Excitable Scale Free Networks

, 2007
When a simple excitable system is continuously stimulated by a Poissonian external source, the response function (mean activity versus stimulus rate) generally shows a linear saturating shape.
Albert, Amaral, Barabási, Beggs, Campos, Castellano, Chialvo, Copelli, Copelli, Deans, Doiron, Eguíluz, Eigen, Firestein, Furtado, Greenberg, Haldeman, Jeong, Jeong, Kinouchi, Lewis, M. Copelli, Milo, Milo, Moreno, Newman, P. R.A. Campos, Rospars, Rospars, Sakata, Sporns, Vuorinen, Watts, Wu   +33 more
core   +1 more source

Identification in dynamic networks [PDF]

Computers & Chemical Engineering, 2018
System identification is a common tool for estimating (linear) plant models as a basis for model-based predictive control and optimization. The current challenges in process industry, however, ask for data-driven modelling techniques that go beyond the single unit/plant models.
Van den Hof, Paul M.J., Dankers, Arne G., Weerts, Harm H.M.   +2 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Public Goods Games on Coevolving Social Network Models

Frontiers in Physics, 2020
Public good games are a metaphor for modeling cooperative behavior in groups in the presence of incentives to free ride. In the model presented here agents play a public good game with their neighbors in a social network structure. Agents' decision rules
Marco Tomassini, Alberto Antonioni
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source