Results 71 to 80 of about 426,852 (266)
IEEE AccessObject detection research has evolved through different architectural paradigms, including two-stage region-based models, one-stage efficiency-focused detectors, and more recent transformer methods, where each performs well in a specific domain but none ...
Oussama Hmidani, El Mehdi Ismaili Alaoui
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Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Time-Varying Networks of Inter-Ictal Discharging Reveal Epileptogenic Zone
Frontiers in Computational Neuroscience, 2017 The neuronal synchronous discharging may cause an epileptic seizure. Currently, most of the studies conducted to investigate the mechanism of epilepsy are based on EEGs or functional magnetic resonance imaging (fMRI) recorded during the ictal discharging
Luyan Zhang +14 more
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Journal of Research on Adolescence, 2013 Researchers have become increasingly interested in disentangling selection and influence processes. This literature review provides context for the special issue on network–behavior dynamics. It brings together important conceptual, methodological, and empirical contributions focusing on longitudinal social network modeling.
Veenstra, René +3 more
openaire +3 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Network Physiology of Cortico–Muscular Interactions
Frontiers in Physiology, 2020 Skeletal muscle activity is continuously modulated across physiologic states to provide coordination, flexibility and responsiveness to body tasks and external inputs.
Rossella Rizzo +8 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Forman-Ricci Flow for Change Detection in Large Dynamic Data Sets
Axioms, 2016 We present a viable geometric solution for the detection of dynamic effects in complex networks. Building on Forman’s discretization of the classical notion of Ricci curvature, we introduce a novel geometric method to characterize different types of real-
Melanie Weber, Jürgen Jost, Emil Saucan
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source