Results 71 to 80 of about 421,141 (266)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A Unified Theoretical and Deep Learning Framework for Temporal Link Prediction in Dynamic Networks

IEEE Access
Temporal networks extend complex networks by explicitly incorporating the time dimension into the analysis of entities and their interactions. With the rapid growth of large-scale social and information networks, modeling time-evolving relationships has ...
Jo Cheriyan, Lekshmi S. Nair, Pao-Ann Hsiung   +2 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

DNM-EWS: A Dynamic Complex Network Framework for Propagation Malware Detection and Early Warning

Jordanian Journal of Computers and Information Technology
The rapid propagation of malware within complex enterprise and Internet Service Provider (ISP) networks poses a critical and growing cybersecurity challenge.
Shorouq Al-eidi
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Optimisation of sparse deep autoencoders for dynamic network embedding

CAAI Transactions on Intelligence Technology
Network embedding (NE) tries to learn the potential properties of complex networks represented in a low‐dimensional feature space. However, the existing deep learning‐based NE methods are time‐consuming as they need to train a dense architecture for deep
Huimei Tang, Yutao Zhang, Lijia Ma, Qiuzhen Lin, Liping Huang, Jianqiang Li, Maoguo Gong   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Foreword: Time and Temporality as Categories of Connectedness

Journal of Historical Network Research
Time and temporality need to be considered essential concepts when studying networks of the past. Their implementation, however, introduces varying forms of complexity, which provides challenges to navigate when operationalized as attributes of ...
Cindarella Petz, Aline Deicke, Julian Jarosch   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Origin of Dynamic Network Formation of 2D Nanofillers in a Flexible Matrix

Small Structures
The aggregation of carbon nanofillers within polymer matrices is a crucial phenomenon for the formation of conducting channels in electrically conductive composites.
Debmalya Roy, Vaishnav B, Subhash Mandal, Ajay Gupta, Benedikt Sochor, Sarathlal Koyiloth Vayalil, Tobias Kraus   +6 more
doaj   +1 more source