Results 81 to 90 of about 2,074,615 (279)

TermBall: Tracking and Predicting Evolution Types of Research Topics by Using Knowledge Structures in Scholarly Big Data

IEEE Access, 2020
The exponential growth in the number of publications and the prevalence of interdisciplinary research in recent years call for new approaches for analyzing how topics in science are evolving at large. This paper proposes TermBall, a framework that tracks
Christine Balili, Uichin Lee, Aviv Segev, Jaejeung Kim, Minsam Ko   +4 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Unified Theoretical and Deep Learning Framework for Temporal Link Prediction in Dynamic Networks

IEEE Access
Temporal networks extend complex networks by explicitly incorporating the time dimension into the analysis of entities and their interactions. With the rapid growth of large-scale social and information networks, modeling time-evolving relationships has ...
Jo Cheriyan, Lekshmi S. Nair, Pao-Ann Hsiung   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Time-Varying Networks of Inter-Ictal Discharging Reveal Epileptogenic Zone

Frontiers in Computational Neuroscience, 2017
The neuronal synchronous discharging may cause an epileptic seizure. Currently, most of the studies conducted to investigate the mechanism of epilepsy are based on EEGs or functional magnetic resonance imaging (fMRI) recorded during the ictal discharging
Luyan Zhang, Yi Liang, Yi Liang, Fali Li, Hongbin Sun, Hongbin Sun, Wenjing Peng, Peishan Du, Peishan Du, Yajing Si, Limeng Song, Liang Yu, Liang Yu, Peng Xu, Peng Xu   +14 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Optimisation of sparse deep autoencoders for dynamic network embedding

CAAI Transactions on Intelligence Technology
Network embedding (NE) tries to learn the potential properties of complex networks represented in a low‐dimensional feature space. However, the existing deep learning‐based NE methods are time‐consuming as they need to train a dense architecture for deep
Huimei Tang, Yutao Zhang, Lijia Ma, Qiuzhen Lin, Liping Huang, Jianqiang Li, Maoguo Gong   +6 more
doaj   +1 more source

Foreword: Time and Temporality as Categories of Connectedness

Journal of Historical Network Research
Time and temporality need to be considered essential concepts when studying networks of the past. Their implementation, however, introduces varying forms of complexity, which provides challenges to navigate when operationalized as attributes of ...
Cindarella Petz, Aline Deicke, Julian Jarosch   +2 more
doaj   +1 more source

Network Physiology of Cortico–Muscular Interactions

Frontiers in Physiology, 2020
Skeletal muscle activity is continuously modulated across physiologic states to provide coordination, flexibility and responsiveness to body tasks and external inputs.
Rossella Rizzo, Rossella Rizzo, Xiyun Zhang, Xiyun Zhang, Jilin W. J. L. Wang, Fabrizio Lombardi, Plamen Ch. Ivanov, Plamen Ch. Ivanov, Plamen Ch. Ivanov   +8 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source