Results 81 to 90 of about 6,062,729 (295)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Bayesian topology identification of linear dynamic networks
, 2019 In networks of dynamic systems, one challenge is to identify the interconnection structure on the basis of measured signals. Inspired by a Bayesian approach in [1], in this paper, we explore a Bayesian model selection method for identifying the ...
Control Systems +4 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
A Unified Theoretical and Deep Learning Framework for Temporal Link Prediction in Dynamic Networks
IEEE AccessTemporal networks extend complex networks by explicitly incorporating the time dimension into the analysis of entities and their interactions. With the rapid growth of large-scale social and information networks, modeling time-evolving relationships has ...
Jo Cheriyan +2 more
doaj +1 more source
The minimum cost multicommodity flow problem in dynamic networks and an algorithm for its solving [PDF]
Computer Science Journal of Moldova, 2005 The dynamic version of the minimum cost multicommodity flow problem that generalizes the static minimum cost multicommodity flow problem is formulated and studied.
Maria A. Fonoberova, Dmitrii D. Lozovanu
doaj
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
DNM-EWS: A Dynamic Complex Network Framework for Propagation Malware Detection and Early Warning
Jordanian Journal of Computers and Information TechnologyThe rapid propagation of malware within complex enterprise and Internet Service Provider (ISP) networks poses a critical and growing cybersecurity challenge.
Shorouq Al-eidi
doaj +1 more source
Journal of Research on Adolescence, 2013 Researchers have become increasingly interested in disentangling selection and influence processes. This literature review provides context for the special issue on network–behavior dynamics. It brings together important conceptual, methodological, and empirical contributions focusing on longitudinal social network modeling.
Veenstra, René +3 more
openaire +3 more sources
Genetic algorithms with elitism-based immigrants for dynamic shortest path problem in mobile ad hoc networks [PDF]
, 2009 This article is posted here with permission from the IEEE - Copyright @ 2009 IEEEIn recent years, the static shortest path (SP) problem has been well addressed using intelligent optimization techniques, e.g., artificial neural networks (ANNs), genetic ...
Yang, S +5 more
core +1 more source