Results 61 to 70 of about 6,062,729 (295)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
International Journal of Bifurcation and Chaos, 2005 Networks have been studied mainly by statistical methods which emphasize their topological structure. Here, one collects some mathematical tools and results which might be useful to study both the dynamics of agents living on the network and the networks themselves as evolving dynamical systems.
openaire +4 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
CoRR, 2016 In a traditional convolutional layer, the learned filters stay fixed after training. In contrast, we introduce a new framework, the Dynamic Filter Network, where filters are generated dynamically conditioned on an input. We show that this architecture is a powerful one, with increased flexibility thanks to its adaptive nature, yet without an excessive ...
Xu Jia 0012 +3 more
openaire +4 more sources
Accountability in Dynamic Networks [PDF]
Proceedings of the 18th International Conference on Distributed Computing and Networking, 2017 We take a game theoretical approach to determine necessary and sufficient conditions under which we can persuade rational agents to exchange messages in pairwise exchanges over links of a dynamic network, by holding them accountable for deviations with punishments.
Xavier Vilaça, Luís E. T. Rodrigues
openaire +4 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Genetic algorithms with immigrants and memory schemes for dynamic shortest path routing problems in mobile ad hoc networks [PDF]
, 2010 This article is posted here with permission of IEEE - Copyright @ 2010 IEEEIn recent years, the static shortest path (SP) problem has been well addressed using intelligent optimization techniques, e.g., artificial neural networks, genetic algorithms (GAs)
Yang, S +5 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An Enhanced Incremental SVD Algorithm for Change Point Detection in Dynamic Networks
IEEE Access, 2018 Change point detection is essential to understand the time-evolving structure of dynamic networks. Recent research shows that a latent semantic indexing (LSI)-based algorithm effectively detects the change points of a dynamic network.
Yongsheng Cheng, Jiang Zhu, Xiaokang Lin
doaj +1 more source