Results 71 to 80 of about 3,942,699 (304)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Online Dynamic Programming

CoRR, 2017
We propose a general method for combinatorial online learning problems whose offline optimization problem can be solved efficiently via a dynamic programming algorithm defined by an arbitrary min-sum recurrence. Examples include online learning of Binary Search Trees, Matrix-Chain Multiplications, $k$-sets, Knapsacks, Rod Cuttings, and Weighted ...
Holakou Rahmanian, S. V. N. Vishwanathan, Manfred K. Warmuth   +2 more
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Fuel-Optimal Thrust-Allocation Algorithm Using Penalty Optimization Programing for Dynamic-Positioning-Controlled Offshore Platforms

Energies, 2018
This research, a new thrust-allocation algorithm based on penalty programming is developed to minimize the fuel consumption of offshore vessels/platforms with dynamic positioning system.
Se Won Kim, Moo Hyun Kim
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Persistently optimal policies in stochastic dynamic programming with generalized discounting [PDF]

In this paper we study a Markov decision process with a non-linear discount function. Our approach is in spirit of the von Neumann-Morgenstern concept and is based on the notion of expectation.
Jaśkiewicz, Anna, Nowak, Andrzej S., Matkowski, Janusz   +2 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Adaptive control of plug-in hybrid electric vehicles based on energy management strategy and dynamic programming algorithm

International Journal of Renewable Energy Development
This study mainly analyses the fuel consumption of plug-in hybrid vehicles during operation. A new control method for automobiles based on energy management strategy and dynamic programming algorithm is proposed.
Yuxin Ge
doaj   +1 more source

Dynamic Programming Strategies on the Decision Tree Hidden behind the Optimizing Problems

Informatics in Education, 2007
The aim of the paper is to present the characteristics of certain dynamic programming strategies on the decision tree hidden behind the optimizing problems and thus to offer such a clear tool for their study and classification which can help in the ...
Zoltan KATAI
doaj   +1 more source