Results 91 to 100 of about 3,221,773 (299)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Similarity Measure Based on Incremental Warping Window for Time Series Data Mining

IEEE Access, 2019
A similarity measure is one of the most important tasks in the fields of time series data mining. Its quality often affects the efficiency and effectiveness of the related algorithms that need to measure the similarity between two time series in advance.
Hailin Li, Cheng Wang
doaj   +1 more source

Stochastic dynamic modeling of short gene expression time-series data [PDF]

, 2008
Copyright [2008] IEEE. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's products or services.
Ho, DWC, Liu, X, Swift, S, Tucker, A, Wang, Z, Yang, F   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CONSIDERATIONS REGARDING THE EVOLUTION OF GROSS DOMESTIC EXPENDITURE ON R&D (GERD) IN ROMANIA AND EU COUNTRIES. PART II – DYNAMIC RHYTHMS [PDF]

Journal of Defense Resources Management
In this paper we have analyzed the evolution of Gross Domestic Expenditure on R&D (GERD) in Romania and EU countries on the last ten years with the available data (2013-2022) provided by the EUROSTAT database.
Cristina ANTONOAIE
doaj  

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Dynamic Performance of Concrete Considering Initial Stresses and Creep

Железобетонные конструкции
In accidental design situations, the loading mode of reinforced concrete structures includes two typical stages such as long-term deformation under constant or slowly varying load and dynamic impact.
S. Yu. Savin, M. Z. Sharipov
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Research on Correlation Analysis for Multidimensional Time Series Based on the Evolution Synchronization of Network Topology

Mathematics
We apply the inherent dynamic consistency of a dynamic system as the basis for correlation analysis among different variables in a system. We use network analysis to measure the correlativity of multiple variables, find the interdependence between ...
Hongduo Cao, Ying Li
doaj   +1 more source

TSEE: an elastic embedding method to visualize the dynamic gene expression patterns of time series single-cell RNA sequencing data

BMC Genomics, 2019
Background Time series single-cell RNA sequencing (scRNA-seq) data are emerging. However, the analysis of time series scRNA-seq data could be compromised by 1) distortion created by assorted sources of data collection and generation across time samples ...
Shaokun An, Liang Ma, Lin Wan
doaj   +1 more source