Results 71 to 80 of about 10,612,437 (315)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Sub-Wavelength Plasmonic Crystals: Dispersion Relations and Effective Properties [PDF]
, 2009 We obtain a convergent power series expansion for the first branch of the dispersion relation for subwavelength plasmonic crystals consisting of plasmonic rods with frequency-dependent dielectric permittivity embedded in a host medium with unit ...
Fortes, Santiago +2 more
core +4 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
MULTISCALED CROSS-CORRELATION DYNAMICS IN FINANCIAL TIME-SERIES [PDF]
Advances in Complex Systems, 2009 The cross-correlation matrix between equities comprises multiple interactions between traders with varying strategies and time horizons. In this paper, we use the Maximum Overlap Discrete Wavelet Transform to calculate correlation matrices over different time–scales and then explore the eigenvalue spectrum over sliding time-windows.
Conlon, Thomas +2 more
openaire +6 more sources
Pauli's Principle in Probe Microscopy [PDF]
, 2014 Exceptionally clear images of intramolecular structure can be attained in dynamic force microscopy through the combination of a passivated tip apex and operation in what has become known as the "Pauli exclusion regime" of the tip-sample interaction.
A Riss +47 more
core +2 more sources
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Functional Principal Component Analysis for Non-stationary Dynamic Time Series [PDF]
, 2018 Motivated by a highly dynamic hydrological high-frequency time series, we propose time-varying Functional Principal Component Analysis (FPCA) as a novel approach for the analysis of non-stationary Functional Time Series (FTS) in the frequency domain ...
Elayouty, Amira +3 more
core
The Algarve climatophilous vegetation series – Portugal: a base document to the planning, management and nature conservation Les séries de végètation climatophiles de l’Algarve - Portugal: un document de base pour la planification, gestion et conservation de la nature [PDF]
, 2012 This work was developed as part of PhD research devoted to the flora and vegetation of the Caldeirão and Monchique mountains that aims to identify the vegetation climatophilous series and use them as an environmental diagnosis of Algarve administrative ...
Cano-Ortiz, Ana +4 more
core +1 more source