Results 51 to 60 of about 17,020,446 (238)

Dynamic Social Networks Logic

open access: yes, 2020
We introduce a general framework for reasoning about dynamic processes within social networks, such as diffusion phenomena. First, we define the new Dynamic Social Networks Logic, a dynamic extension of standard hybrid modal logic.
Jens Ulrik Hansen, Zoé Christoff
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Public Goods Games on Coevolving Social Network Models

open access: yesFrontiers in Physics, 2020
Public good games are a metaphor for modeling cooperative behavior in groups in the presence of incentives to free ride. In the model presented here agents play a public good game with their neighbors in a social network structure. Agents' decision rules
Marco Tomassini, Alberto Antonioni
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Capturing Global Structural Features and Global Temporal Dependencies in Dynamic Social Networks Using Graph Convolutional Networks for Enhanced Analysis

open access: yesJournal of Social Computing
Modeling and analysis of complex social networks is an important topic in social computing. Graph convolutional networks (GCNs) are widely used for learning social network embeddings and social network analysis.
Ling Wu, Boen Li, Kun Guo, Qishan Zhang
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Influence Maximization Algorithm for Dynamic Social Networks Based on Linear Threshold Model

open access: yes工程科学与技术, 2019
In order to solve the influence maximization problem in evolving social network, a dynamic influence maximization algorithm based on the linear threshold model was proposed in this paper.
Jinghua ZHU   +3 more
doaj  

Social-Ecological Connectivity to Understand Ecosystem Service Provision across Networks in Urban Landscapes

open access: yesLand, 2020
Landscape connectivity is a critical component of dynamic processes that link the structure and function of networks at the landscape scale. In the Anthropocene, connectivity across a landscape-scale network is influenced not only by biophysical land use
Monika Egerer, Elsa Anderson
doaj   +1 more source

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