Results 101 to 110 of about 6,987,863 (341)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Temperature dependence of phase stabilities of hexagonal hemicarbides from first principles

open access: yesMaterials Research Express
Transition metal hemicarbides, specifically M _2 C (where M = V, Nb, Ta, Mo and W), have received considerable attention in the fields of catalysis and metallurgy.
Chao Deng   +4 more
doaj   +1 more source

The Scapular’s Roles in Developing Shoulder Complex Function

open access: yesIndonesian Contemporary Nursing Journal
The scapulohumeral anatomy and biomechanics interact to provide adequate mobility, thus the scapula plays various functions in facilitating optimal shoulder complex function (Paine & Voight., 2013).
Rijal Rijal
doaj   +1 more source

DYNAMIC CAPABILITIES AND STRATEGIC MANAGEMENT

open access: yes, 1997
The dynamic capabilities framework analyzes the sources and methods of wealth creation and capture by private enterprise firms operating in environments of rapid technological change.
D. Teece, G. Pisano, A. Shuen
semanticscholar   +1 more source

Stability Analysis for Incremental Nonlinear Dynamic Inversion Control

open access: yesJournal of Guidance Control and Dynamics, 2018
As a sensor-based control method, incremental nonlinear dynamic inversion (INDI) has been applied to various aerospace systems and has shown desirable robust performance against aerodynamic model u...
Xuerui Wang, E. Kampen, Q. Chu, P. Lu
semanticscholar   +1 more source

On Dynamical Stability in General Dynamical Systems

open access: yesJournal of Mathematical Analysis and Applications, 2001
AbstractThis paper is concerned with dynamical stability of general dynamical systems. We discuss invariance properties of some limit sets, investigate connections between various notions and definitions related to stability and attraction properties, and establish existence results for invariant uniform attractors.
openaire   +2 more sources

Stability and Dynamics of the Tetravacancy in Graphene

open access: yesNano Letters, 2014
The relative prevalence of various configurations of the tetravacancy defect in monolayer graphene has been examined using aberration corrected transmission electron microscopy (TEM). It was found that the two most common structures are extended linear defect structures, with the 3-fold symmetric Y-tetravacancy seldom imaged, in spite of this being a ...
Robertson, A   +5 more
openaire   +4 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

Dual-Task Elderly Gait of Prospective Fallers and Non-Fallers: A Wearable-Sensor Based Analysis

open access: yesSensors, 2018
Wearable sensors could facilitate point of care, clinically feasible assessments of dynamic stability and associated fall risk through an assessment of single-task (ST) and dual-task (DT) walking.
Jennifer Howcroft   +3 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

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