Results 101 to 110 of about 2,316,210 (327)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Differences between Male and Female College Students in Dynamic Stability Change through Measuring Lower Extremity Muscle Fatigue [PDF]
, 2019 Hae sung Lee +2 more
openalex +1 more source
Local stability under evolutionary game dynamics [PDF]
We prove that any regular ESS is asymptotically stable under any impartial pairwise comparison dynamic, including the Smith dynamic; under any separable excess payoff dynamic, including the BNN dynamic; and under the best response dynamic.
Sandholm, William H.
core +1 more source
Implementation of a self-controlling heater: A concept [PDF]
, 1974 Proposed heater uses its own temperature coefficient for sensing function. Heating power is supplied from current source, heater voltage containing temperature information.
Strange, M. G.
core +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
DesignsArticulated heavy vehicles exhibit poor lateral stability, which may lead to unstable motion modes, e.g., trailer-sway and jackknifing, causing severe accidents.
Tarun Sharma, Yuping He
doaj +1 more source
International Biomechanics, 2018 The purpose of this study was to examine the mechanism of fall risk in community-dwelling ambulatory hemiplegic stroke survivors when exposed to a sudden, trip-like support surface perturbation in standing.
Mansi Joshi, Prakruti Patel, Tanvi Bhatt
doaj +1 more source