Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Application of signal sparse decomposition in dynamic test
Journal of Measurement Science and Instrumentation, 2013 In dynamic test,sampling rate is high and noise is strong,so a signal sparse decomposition method based on Gabor dictionary is put forward.This method iteratively decomposes the signal with the matching pursuit（MP）algorithm and takes the coherence ratio ...
XUAN Zhi-wei +2 more
doaj
Surgical Management for Posterior Atlantoaxial Dislocation without Fracture and Atlantoaxial Dynamic Test to Confirm the Integrity of the Transverse Ligament: A Case Report. [PDF]
Orthop Surg, 2022 Li C, Li L, Li Z, Mei Y, Huang S.
europepmc +1 more source
Performance and test section flow characteristics of the National Full-Scale Aerodynamics Complex 40- by 80-foot wind tunnel [PDF]
Results from the performance and test section flow calibration of the 40- by 80-Foot Wind Tunnel are presented. A flow calibration test was conducted in May and June 1987. The goal of the flow calibration test was to determine detailed spatial variations
Flack, Karen, Zell, Peter T.
core +1 more source
The specification of cross exchange rate equations used to test Purchasing Power Parity [PDF]
, 2004 The Article considers the speciÞcation of models used to test Pur- chasing Power Parity when applied to cross exchange rates. SpeciÞcally, conventional dynamic models used to test stationarity of the real exchange rate are likely to be misspeciÞed ...
Hunter, J, Simpson, M
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Concept and Realization of a Novel Test Method Using a Dynamic Test Stand for Detecting Persons by Sensor Systems on Autonomous Agricultural Robotics. [PDF]
Sensors (Basel), 2021 Meltebrink C +4 more
europepmc +1 more source
The dynamic mature of the Adams ring arcs - Fraternite, Egalite (2,1), Liberte, Courage
, 2009 By considering the finite mass of Fraternite, the dynamic nature of the Adams ring arcs is regarded as caused by the reaction of a test body (a minor arc) through the Lindblad resonance (LR).
de Pater +11 more
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source