Results 51 to 60 of about 1,135,072 (266)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Hydrogen Hybrid Power System and Its Control Strategy for Autonomous-rail Rapid Tram
Kongzhi Yu Xinxi Jishu, 2023 In the context of increasing application of autonomous-rail rapid transit (ART) at home and abroad, in order to meet the diverse power system requirements in various scenarios and the operating range demands in different operation modes, this paper ...
YU Zhuo, XIAO Lei, XIE Jun, LI Jing
doaj
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Experimental Calculation of Added Masses for the Accurate Construction of Airship Flight Models
AerospaceIn recent years, interest in airships for cargo transport and stratospheric platforms has increased, necessitating accurate dynamic modeling for stability analysis, autopilot design, and mission planning, specifically through the calculation of stability
Deibi López +4 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Saudi Endodontic Journal, 2018 Aim: This study aims to compare the cyclic fatigue resistance of new and used ProTaper Universal (PTU) and ProTaper Next (PTN) rotary nickel-titanium systems using artificial canals.
Neslihan Büşra Keskin +3 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Experimental Study on Dynamic Effects of a Long-span Railway Continuous Beam Bridge
Applied Sciences, 2018 Studies on impact effects of trains on the railway bridge are important for ensuring the reliability of bridge and the safety of train operation. This paper presents an experimental study on the dynamic effects of moving trains on a long-span railway ...
Hongye Gou +4 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source