Movement Disorders, EarlyView.Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard +33 more
wiley +1 more source
Improved multi-strategy secretary bird optimization for efficient IoT task scheduling in fog cloud computing. [PDF]
Sci RepSangeetha K, Kanthimathi M.
europepmc +1 more source
Movement Disorders, EarlyView.Abstract Background The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...
Mirco Macchi +127 more
wiley +1 more source
Eco-FinOps: a causal-agentic framework for energy-efficient and explainable cloud cost optimization. [PDF]
Front Artif IntellSreejindeth P, Padmavathy T.
europepmc +1 more source
Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine
Medicinal Research Reviews, EarlyView.ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli +5 more
wiley +1 more source
From visual attention to behavioural intention: A relational framework of culturally creative desserts in museum communication. [PDF]
PLoS OneKe Z, Meng X, Xu J, Mustafa M.
europepmc +1 more source
Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications
Portal Hypertension &Cirrhosis, EarlyView.This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf +8 more
wiley +1 more source
Effects of Multisensory Integration Training on Postural Stability Characteristics and Fall Risk in Older Adults: Systematic Review and Meta-Analysis. [PDF]
JMIR AgingGuo C +10 more
europepmc +1 more source
Synthesis of Poly(Itaconate)s With High Monomer Conversion Applying Emulsion Polymerization
Journal of Polymer Science, Volume 63, Issue 6, Page 1284-1296, 15 March 2025.Itaconic acid and its derivatives are a promising and bio‐based substitute for oil‐based polymers such as acrylates. In this study, the optimization of polymerization of itaconic acid esters is described by applying emulsion polymerization leading to high reaction conversions and low residual monomer contents. ABSTRACT Itaconic acid and its derivatives
S. Charlotte Fischer von Mollard +5 more
wiley +1 more source
The Gut-Ear Axis: From Dysbiosis to Auditory and Vestibular Disorders. [PDF]
Int J Mol SciLi Y, Shi X, Liu X, Sun Y.
europepmc +1 more source