Results 191 to 200 of about 3,781,586 (272)

Integrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...
Mirco Macchi, Aurélien Ginolhac, Tony Heurtaux, Borja Gomez‐Ramos, Lasse Sinkkonen, Enrico Glaab, on behalf of the NCER‐PD Consortium, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlaan, Anne Grünewald, Armin Rauschenberger, Clarissa P.C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez de Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby   +127 more
wiley   +1 more source

Research progress and clinical application of functional magnetic resonance imaging in otolaryngology-head and neck diseases. [PDF]

Front Neurol
Mao M, Chen W, Huang X.
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Dynamic multi objective task scheduling in cloud computing using reinforcement learning for energy and cost optimization. [PDF]

Sci Rep
Yu X, Mi J, Tang L, Long L, Qin X.
europepmc   +1 more source

Inferring Inter‐Well Fracture Interactions in Unconventional Reservoirs Using Fiber‐Optic Sensing and Coupled Multiphysics Modelling

International Journal for Numerical and Analytical Methods in Geomechanics, EarlyView.
ABSTRACT Integrating distributed temperature sensing (DTS) and distributed acoustic sensing (DAS) data with numerical simulations to analyze inter‐well interference and production responses remains challenging. This study employs a coupled thermal–hydraulic–mechanical simulation framework to model heat transfer, fluid flow, and geomechanical responses ...
Chuanyao Zhong, Jiahui Chen, Juliana Y. Leung, Mirko van der Baan   +3 more
wiley   +1 more source

Mapping prefrontal afferents along development. [PDF]

Front Neurosci
Günther A, Stelzer M, Franzelin A, Marquardt A, Oertner TG, Hanganu-Opatz IL, Pöpplau JA.   +6 more
europepmc   +1 more source

Dental Modifications Indicate Social Identity in the Insular Region of Wallacea, Indonesia 3634–2268 Cal BP

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT The dispersal of Austronesian‐speaking people across Island Southeast Asia and the Pacific during the Late Holocene was associated with the spread of shared cultural practices, including intentional dental modifications. These practices, like tooth ablation and dental staining (likely with betel quid), are interpreted as embodied expressions ...
Pratiwi Yuwono, Melandri Vlok, Fayeza Shasliz Arumdhati, Sekar Kinanthi, Renaud Joannes‐Boyau, Maxime Aubert, Mahirta, Marlon Ririmase, Harriyadi, Rama Putra Siswantara, Stuart Hawkins   +10 more
wiley   +1 more source

Implication of the thalamus in sleep alterations observed in Alzheimer's disease. [PDF]

Alzheimers Dement
Burnet-Merlin C, Hay YA, Brécier A.
europepmc   +1 more source

Mechanical Recycling of Hybrid Polypropylene/Recycled Carbon Fiber/Hemp Composite Wall Panels: A Comparative Study of Compression and Injection Molding

Polymer Composites, EarlyView.
Mechanical recycling pathways for hybrid PP/rCF/hemp composite wall panels via compression and injection molding. ABSTRACT Circular economy increasingly influences sectors such as automotive, packaging, and building‐construction. The rise of circular economy in these sectors is driven by the generation of large volumes of waste that end up in landfills,
Chinmay Mungale, Umesh Marathe, Matthew Vaught, Joslin Joshy, Anna Douglas, Hicham Ghossein, Halil Tekinalp, Soydan Ozcan, Uday Vaidya   +8 more
wiley   +1 more source