Results 191 to 200 of about 3,200,353 (267)

Intensity Noise Dynamics in Terahertz Quantum Cascade Lasers

open access: yesLaser &Photonics Reviews, EarlyView.
Intensity‐noise dynamics in terahertz quantum cascade lasers are investigated across single‐mode, dense‐comb and harmonic‐comb regimes using graphene thermoelectric detectors. Harmonic combs show ∼10% lower relative intensity noise, while RIN scales as P0−γ$P_0^{ - \gamma }$ with γ≈1.2$\gamma \approx 1.2$, revealing a crossover from spontaneous ...
M. Alejandro Justo‐Guerrero   +5 more
wiley   +1 more source

NKX2‐1 Downstream Regulatory Structural Variants Explain a Substantial Proportion of Molecular Diagnoses in Patients With Benign Hereditary Chorea

open access: yesMovement Disorders, EarlyView.
Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard   +33 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...
Mirco Macchi   +127 more
wiley   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli   +5 more
wiley   +1 more source

Human In Vivo Validation of Frequency‐Dependent QTI

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose The aim of this work is to investigate if q‐space trajectory imaging (QTI) waveforms can be designed to probe QTI metrics at a single centroid frequency under realistic experimental conditions for in vivo human brain imaging. Methods Realistic diffusion encoding waveforms based on double‐rotation gradient waveform and magic‐angle ...
Svenja Niesen   +3 more
wiley   +1 more source

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