Results 101 to 110 of about 448 (262)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Modulation strategy of dynamic voltage restorer based on dual-feedforward active disturbance rejection compound controller

Frontiers in Energy Research
Given the contradiction between compensating speed and compensating overshoot in traditional Proportional Integral (PI) control of Dynamic Voltage Restorer (DVR), A Feedforward compensation-active Disturbance Rejection Control (FC-ADRC) strategy based on
Langchen Huang, Weiling Liu, Ning Zhang, Qingyun Yan, Xinwei Wei   +4 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Performance enhancement of a dynamic voltage restorer

TURKISH JOURNAL OF ELECTRICAL ENGINEERING & COMPUTER SCIENCES, 2017
Latha Pappath Vasudevan, Valsalal Prasad
openaire   +2 more sources

Enhanced control of DFIG using fuzzy backstepping under asymmetrical voltage dips with dynamic voltage restorer

Engineering Science and Technology, an International Journal
This paper presents a coordinated control strategy for a doubly fed induction generator (DFIG) under asymmetrical voltage dips, combining a Dynamic Voltage Restorer based on hysteresis voltage control (DVR–HVC) with a fuzzy backstepping controller (FBSC)
Abdelhalim Arif, Mohamed Naoui, Youcef Bekakra, Mansoor Alturki, Yasser Almalaq, Abdullah Albaker, Badr M. Alshammari, Tawfik Guesmi   +7 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Fuzzy logic-controlled three-phase dynamic voltage restorer for enhancing voltage stabilization and power quality

International Journal of Electrical Power & Energy Systems
Enhancing power quality (PQ) in electrical distribution systems is vital for maintaining a stable and reliable power supply, especially for sensitive industrial and commercial loads prone to voltage disturbances.
Abu Shufian, Sowrov Komar Shib, Durjoy Roy Dipto, Md Tanvir Rahman, Nasif Hannan, Shaikh Anowarul Fattah   +5 more
doaj   +1 more source

Optimizing Adaptive Disturbance Rejection Control Models Using the Chimp Optimization Algorithm for Ships' Hybrid Renewable Energy Systems. [PDF]

Comput Intell Neurosci, 2022
Amlashi AG, Rezvani M, Radmehr M, Ghafouri A.   +3 more
europepmc   +1 more source