Results 81 to 90 of about 448 (262)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

A detection algorithm of voltage sag used in dynamic voltage restorer

open access: yesGong-kuang zidonghua, 2013
In view of contradiction between compensation rapidity and anti-interference performance existed in traditional detection algorithm of voltage sag of d-q detection algortihom and Hilbert detection algorithm, a new detection algorithm of voltage sag ...
TIAN Ming, WANG Chang-nan, HE Cheng
doaj  

Enhanced Power Quality in Photovoltaic-Fed Dynamic Voltage Restorer Using an Adaptive Grey Wolf Optimization Algorithm for Multilevel Inverter Control [PDF]

open access: yesE3S Web of Conferences
In this paper, we investigate the power quality improvement in a photovoltaic-fed dynamic voltage restorer (DVR) system by utilizing a multilevel inverter controlled through the Adaptive Grey Wolf Optimization (GWO) algorithm.
Mundher Adnan Myasar   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Dynamic Voltage Restorer (DVR) for Voltage Sag Mitigation

open access: yesInternational Journal on Electrical Engineering and Informatics, 2011
The Dynamic Voltage Restorer (DVR) is fast, flexible and efficient solution to voltage sag problem. The DVR is a power electronic based device that provides three-phase controllable voltage source, whose voltage vector (magnitude and angle) adds to the source voltage during sag event, to restore the load voltage to pre-sag conditions.
Mahmoud A. El-Gammal   +2 more
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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